Role of tumor necrosis factor alpha in the pathogenesis of atrial fibrillation: A novel potential therapeutic target?

Annals of Medicine
Manyi RenJingquan Zhong

Abstract

Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice and a major cause of morbidity and mortality. Although the fundamental mechanisms underlying AF remain incompletely understood, atrial remodeling, including structural, electrical, contractile, and autonomic remodeling, has been demonstrated to contribute to the substrate for AF maintenance. Accumulating evidence shows that tumor necrosis factor alpha (TNF-α) plays exceedingly important roles in atrial remodeling. This article reviews recent advances in the roles of TNF-α in the pathogenesis of AF, elucidates the related mechanisms, and exploits its potential usefulness as a novel therapeutic target.

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Citations

Apr 6, 2017·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Qingyan ZhaoCongxin Huang
Feb 9, 2018·Journal of the American Heart Association·Farhan ShahidEduard Shantsila
Aug 20, 2020·Journal of Cellular and Molecular Medicine·Yun-Long ZhangHui-Hua Li
Apr 26, 2017·Molecular Medicine Reports·Ying-Ying ChenLiang-Rong Zheng
Feb 9, 2021·Journal of Electrocardiology·Saban KelesogluDeniz Elcık
Mar 6, 2021·Journal of Arrhythmia·Nso NsoFarshid Radparvar

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