Role of tumor necrosis factor alpha in the pathogenesis of atrial fibrillation: A novel potential therapeutic target?

Annals of Medicine
Manyi RenJingquan Zhong


Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice and a major cause of morbidity and mortality. Although the fundamental mechanisms underlying AF remain incompletely understood, atrial remodeling, including structural, electrical, contractile, and autonomic remodeling, has been demonstrated to contribute to the substrate for AF maintenance. Accumulating evidence shows that tumor necrosis factor alpha (TNF-α) plays exceedingly important roles in atrial remodeling. This article reviews recent advances in the roles of TNF-α in the pathogenesis of AF, elucidates the related mechanisms, and exploits its potential usefulness as a novel therapeutic target.


Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E A CarswellB Williamson
Sep 1, 1992·The Journal of Clinical Investigation·B P GiroirB Beutler
Dec 14, 1996·Journal of the Autonomic Nervous System·C AbadieR Nadeau
Jul 1, 1997·Journal of Molecular and Cellular Cardiology·S E Campbell, L C Katwa
Jan 5, 1999·International Journal of Cardiology·J L HuangS A Chen
Mar 7, 2000·Pediatrics International : Official Journal of the Japan Pediatric Society·T JibikiH Niimi
Jun 21, 2001·The American Journal of Geriatric Cardiology·Porur SomasundaramMichael F. Wilson
Apr 2, 2002·Cardiovascular Research·William S BradhamFrancis G Spinale
Apr 19, 2002·The Journal of Pharmacology and Experimental Therapeutics·Bernie ScallonCarrie Wagner
Jun 14, 2002·Cardiovascular Research·Maurits AllessieUlrich Schotten
Sep 5, 2002·Arthritis and Rheumatism·Philippe DieudéUNKNOWN European Consortium on Rheumatoid Arthritis Families
Mar 26, 2003·Cell Death and Differentiation·H WajantP Scheurich
Mar 19, 2004·Journal of Cardiovascular Electrophysiology·Prapa KanagaratnamNicholas S Peters
Jun 26, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Fiorella CalabreseGaetano Thiene
Sep 4, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Lena BrånénStefan Jovinge
Dec 14, 2004·Congestive Heart Failure·Lou Vadlamani, Srinivas Iyengar
Apr 26, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Renqiang ZouStanley Nattel
Jun 1, 2005·The American Journal of Cardiology·Guillermo Torre-Amione

❮ Previous
Next ❯


Apr 6, 2017·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Qingyan ZhaoCongxin Huang
Feb 9, 2018·Journal of the American Heart Association·Farhan ShahidEduard Shantsila
Aug 20, 2020·Journal of Cellular and Molecular Medicine·Yun-Long ZhangHui-Hua Li
Apr 26, 2017·Molecular Medicine Reports·Ying-Ying ChenLiang-Rong Zheng
Feb 9, 2021·Journal of Electrocardiology·Saban KelesogluDeniz Elcık
Mar 6, 2021·Journal of Arrhythmia·Nso NsoFarshid Radparvar

❮ Previous
Next ❯

Related Concepts

Related Feeds


Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Related Papers

Journal of Cardiovascular Pharmacology
Alex Y Tan, Peter J Zimetbaum
Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Carina LammersCarsten Zobel
The Annals of Thoracic Surgery
Herko GrubitzschWolfgang Konertz
© 2021 Meta ULC. All rights reserved