PMID: 9423858Jan 10, 1998Paper

Role of tumor necrosis factor alpha in gnotobiotic mice infected with an Escherichia coli O157:H7 strain

Infection and Immunity
E IsogaiK Takeshi

Abstract

Gnotobiotic mice inoculated with an enterohemorrhagic Escherichia coli (EHEC) O157:H7 strain developed a flaccid paresis, usually culminating in death. The bacteria colonized feces at 10(9) to 10(10) CFU per g (inoculum size: 2.0 x 10(9) CFU/mouse), and Shiga-like toxins (SLTs) were detected in the feces. A microscopic examination of colons showed mild inflammatory cell infiltration, thinning of the intestinal wall, or necrotic foci. Necrosis of tubular cells was noted in these symptomatic mice. Microhemorrhage, thrombosis, and edematous changes of the brain were also seen. Inflammatory cytokines, tumor necrosis factor alpha (TNF-alpha), interleukin 1alpha (IL-1alpha), and IL-6, were detected in the kidney after EHEC infection, but not in the serum. In the brain, only TNF-alpha was detected. When 2.0 x 10(2) CFU of EHEC O157:H7 was fed to germ-free mice, the number of bacteria began to rise rapidly on day 1 and was maintained at 10(8)to 10(9) CFU/g of feces. SLTs were detected in the feces of the mice. However, the mice showed no histological changes and no cytokine responses, similar to what was found for controls. Treatment with TNF-alpha modified the clinical neural signs, histopathological changes, and cytokine responses; m...Continue Reading

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Citations

Oct 9, 2012·The Journal of Clinical Investigation·Emily M MallickDavid B Schauer
Jul 1, 2020·Neural Regeneration Research·George Zaki Ghali, Michael George Zaki Ghali
Jul 31, 2001·Pediatric Research·F ProulxD Karpman
Jul 12, 2002·American Journal of Physiology. Renal Physiology·Allison A Eddy
Jun 16, 2004·FEMS Immunology and Medical Microbiology·Motomichi TakahashiShigeru Kamiya
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Apr 21, 2007·Microbiology and Immunology·Byeonghwa Jeon, Kikuji Itoh
Jan 29, 2011·Journal of Biomedicine & Biotechnology·Krystle L Mohawk, Alison D O'Brien
Apr 30, 2008·Infection and Immunity·Kathryn A EatonThomas S Whittam
Oct 1, 2014·Infection and Immunity·Alexander CorbishleyTom N McNeilly
Jan 27, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ramon Alfonso ExeniMarina Sandra Palermo
Sep 23, 2000·Journal of Biotechnology·G IgnatyevW Lubitz
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Feb 21, 2006·Research in Microbiology·Guillaume DalmassoDorota Czerucka

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