Role of tumour necrosis factor alpha converting enzyme (TACE/ADAM17) and associated proteins in coronary artery disease and cardiac events

Archives of Cardiovascular Diseases
Melody ChemalyAaron Peace

Abstract

Tumour necrosis factor alpha converting enzyme (TACE/ADAM17) is a member of the A disintegrin and metalloproteinase (ADAM) family of ectodomain shedding proteinases. It regulates many inflammatory processes by cleaving several transmembrane proteins, including tumour necrosis factor alpha (TNFα) and its receptors tumour necrosis factor alpha receptor 1 and tumour necrosis factor alpha receptor 2. There is evidence that TACE is involved in several inflammatory diseases, such as ischaemia, heart failure, arthritis, atherosclerosis, diabetes and cancer as well as neurological and immune diseases. This review summarizes the latest discoveries regarding the mechanism of action and regulation of TACE. It also focuses on the role of TACE in atherosclerosis and coronary artery disease (CAD), highlighting clinical studies that have investigated its expression and protein activity. The multitude of substrates cleaved by TACE make this enzyme an attractive target for therapy and a candidate for biomarker research and development in CAD.

Citations

Apr 14, 2020·Expert Opinion on Drug Discovery·Prashant R MurumkarMange Ram Yadav
Jun 20, 2020·Brazilian Dental Journal·Cyro José de Almeida GuardiolaMarcelo Henrique Napimoga
Jul 8, 2020·The Journal of Thoracic and Cardiovascular Surgery·Finosh G Thankam, Devendra K Agrawal
Oct 15, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Claire C MunierMatthew W D Perry

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