Role of two-component systems in the virulence of Streptococcus pneumoniae

Journal of Medical Microbiology
G K PatersonT J Mitchell

Abstract

Understanding of how the human pathogen Streptococcus pneumoniae perceives and responds to its environment in the host offers insight into the pathogenesis of disease caused by this important bacterium and the potential for improved interventions. A central role in this environmental response is played by two-component systems (TCSs), which both sense the environment and drive the cellular response. Molecular advances in the form of genome sequencing, signature-tagged mutagenesis, differential fluorescence induction and microarray analysis have yielded considerable progress in the study of these systems in S. pneumoniae. These recent advances are discussed here, focusing in particular on the role of TCSs in the virulence of S. pneumoniae.

References

Jul 14, 1998·Antimicrobial Agents and Chemotherapy·J F Barrett, J A Hoch
Jun 15, 1999·Journal of Bacteriology·P K MartinM B Schmid
Nov 24, 1999·Molecular Microbiology·R DuttaM Inouye
Feb 15, 2000·Molecular Microbiology·J P ThroupM K Burnham
Apr 4, 2000·Current Opinion in Microbiology·J A Hoch
Aug 31, 2000·Annual Review of Biochemistry·A M StockP N Goudreau
May 22, 2001·Molecular Microbiology·G W LauD W Holden
Jul 23, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Jean-Pierre Claverys, Leiv Sigve Havarstein
Sep 10, 2002·Trends in Microbiology·Chantal Guidi-Rontani
Oct 16, 2002·Infection and Immunity·Christian WagnerMalcolm G Page
Dec 18, 2002·Journal of Bacteriology·Thorsten MascherRegine Hakenbeck
Mar 27, 2003·Acta Crystallographica. Section D, Biological Crystallography·Colin J BentAlan Riboldi-Tunnicliffe
Apr 22, 2003·Infection and Immunity·Sabine Chapuy-RegaudMarie-Claude Trombe
Jul 18, 2003·Journal of Molecular Microbiology and Biotechnology·Valerie A ClausenNicola G Wallis
Oct 24, 2003·Infection and Immunity·Aras KadiogluPeter W Andrew
Apr 23, 2004·Acta Crystallographica. Section D, Biological Crystallography·Alan Riboldi-TunnicliffeTimothy J Mitchell
May 20, 2004·Vaccine·D BogaertR de Groot
May 25, 2004·Infection and Immunity·Yasser Musa IbrahimTim J Mitchell
Jul 17, 2004·Molecular Microbiology·Lauren J McAllisterJames C Paton

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Citations

Mar 11, 2009·Antimicrobial Agents and Chemotherapy·Petra BeckerBernhard Henrich
Apr 30, 2008·Infection and Immunity·Jason W RoschElaine Tuomanen
Jun 5, 2012·Journal of Bacteriology·Virtu Solano-ColladoAlicia Bravo
Nov 7, 2006·Journal of Bacteriology·Wouter T HendriksenTim J Mitchell
Jan 16, 2007·Journal of Bacteriology·Zhuo Ma, Jing-Ren Zhang
Jul 19, 2012·PLoS Pathogens·Beth MannJason W Rosch
Jul 30, 2011·Future Microbiology·Kellie Burnside, Lakshmi Rajagopal
May 26, 2010·Molecular Microbiology·Annalisa LemboLakshmi Rajagopal
Jan 20, 2018·Medical Sciences : Open Access Journal·Mary F NakamyaBindu Nanduri
Jan 22, 2013·MedChemComm·Samson FrancisErin E Carlson
May 5, 2020·BioImpacts : BI·Bhavya Somalapura GangadharappaGajanan Sathe
Oct 23, 2020·Proceedings of the National Academy of Sciences of the United States of America·Robin A SorgJan-Willem Veening

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