PMID: 2123970Oct 1, 1990Paper

Role of type A and B monoamine oxidase on the formation of 3,4-dihydroxyphenylacetic acid (DOPAC) in tissues from the brain of the rat

Neuropharmacology
M C Garrett, P Soares-da-Silva

Abstract

The role of monamine oxidase (MAO), type A and B, on the deamination of dopamine in the striatum, nucleus accumbens and frontal cortex of the rat was studied. Levels of dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) tissue were quantified by means of high pressure liquid chromatography with electrochemical detection. Rats were given pargyline (75 mg/kg), selegyline (5 mg/kg) or clorgyline (2 mg/kg) by the intraperitoneal route, 60 min before sacrifice; in another set of experiments, clorgyline (2 mg/kg, i.p.) was given 15 or 30 min before sacrifice. Only clorgyline and pargyline were found to reduce significantly the formation of DOPAC and HVA in all the three areas of brain under study (83-97% reduction). The inhibition of deamination of dopamine by clorgyline and pargyline was accompanied by an increase in levels of dopamine in tissue. The increase of the levels of amine in tissue, as a result of inhibition of MAOA was more marked in the frontal cortex (52% increase) and the accumbens (39% increase), than in the striatum (25% increase). The results suggest that a substantial amount of DOPAC in brain derives from the deamination of dopamine by MAOA.

References

Jan 14, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·P C WaldmeierL Maître
Feb 1, 1987·The Journal of Pharmacy and Pharmacology·P Soares-da-Silva

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Citations

Jul 19, 1991·Brain Research·S Puglisi-AllegraS Cabib
Mar 7, 1998·Life Sciences·J T Guimarães, P Soares-da-Silva
Nov 5, 1999·Pharmacology, Biochemistry, and Behavior·C CohenD J Sanger
Jan 1, 1991·Acta Neurologica Scandinavica. Supplementum·L Oreland
May 20, 1999·Journal of Affective Disorders·O CuretB Scatton
Jan 19, 2007·The European Journal of Neuroscience·Karine GuillemLuis Stinus
Jun 14, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Daniel I Brierley, Colin Davidson
Jul 5, 2016·Neurochemistry International·Lorenzo Antonio JustoLilian Rosana F Faro
Sep 11, 2012·Neuropharmacology·Ingrid MoralesManuel Rodriguez
Sep 10, 2016·Frontiers in Human Neuroscience·Rebecca A Lundwall, Claudia G Rasmussen
Jan 26, 2018·Scientific Reports·Jickssa M GemechuAnna Moszczynska

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