Role of Tyrosine Isomers in Acute and Chronic Diseases Leading to Oxidative Stress - A Review

Current Medicinal Chemistry
Gergő A MolnárIstván Wittmann

Abstract

Oxidative stress plays a major role in the pathogenesis of a variety of acute and chronic diseases. Measurement of the oxidative stress-related end products may be performed, e.g. that of structural isomers of the physiological para-tyrosine, namely meta- and ortho-tyrosine, that are oxidized derivatives of phenylalanine. Recent data suggest that in sepsis, serum level of meta-tyrosine increases, which peaks on the 2(nd) and 3(rd) days (p<0.05 vs. controls), and the kinetics follows the intensity of the systemic inflammation correlating with serum procalcitonin levels. In a similar study subset, urinary meta-tyrosine excretion correlated with both need of daily insulin dose and the insulin-glucose product in non-diabetic septic cases (p<0.01 for both). Using linear regression model, meta-tyrosine excretion, urinary meta-tyrosine/para-tyrosine, urinary ortho-tyrosine/para-tyrosine and urinary (meta- + orthotyrosine)/ para-tyrosine proved to be markers of carbohydrate homeostasis. In a chronic rodent model, we tried to compensate the abnormal tyrosine isomers using para-tyrosine, the physiological amino acid. Rats were fed a standard high cholesterol-diet, and were given para-tyrosine or vehicle orally. High-cholesterol feeding l...Continue Reading

Citations

May 13, 2017·Nutrients·Raul Fernandez-PradoMaria Dolores Sanchez-Niño
Jul 3, 2020·Frontiers in Bioengineering and Biotechnology·Xumin LiTim Forouzanfar
Nov 21, 2019·Immunobiology·Daniela Romina MontagnaBárbara Rearte
Jun 3, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Seema PatelSyed Shams Ul Hassan
Jul 11, 2020·Inorganic Chemistry·Danielle M HamannDavid C Johnson
Nov 18, 2021·Journal of Cellular and Molecular Medicine·Xumin LiGang Wu

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