PMID: 9194028May 1, 1997Paper

Role of tyrosine specific phosphorylation of cellular proteins, especially EGF receptor and p125FAK in human lung cancer cells

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
M ImaizumiM Hamaguchi

Abstract

To clarify the role of tyrosine phosphorylation of cellular proteins in human lung cancer cells, phosphotyrosine (PTYR)-containing proteins in lung cancer cell lines and in paired tissues resected from cancerous and normal lungs were studied by immunoblotting with an anti-PTYR antibody. We found that the profiles of protein phosphorylation were very similar among those cell lines which had different histological features. The major PTYR-containing proteins (180-190 KDa, 120-130 KD, and 95-100 KDa) were detected in lung cancer cell lines. The expression of EGF receptor (EGF-r) (p185) and o-erb B2 protein, and tyrosine phosphorylation of p125FAK were examined in cancerous lung tissues and normal lung tissues. In surgical specimens, approximately half of the samples of lung cancer tissues showed clear elevation of tyrosine phosphorylation. In these cancerous tissues, no clear amplification of EGF-r and c-erb B2 protein expression was observed. However, elevation of tyrosine phosphorylation of p125FAK was observed in cancerous lung tissues but not in normal lung tissues, and its phosphorylation was closely correlated with the nodal involvement of cancer and disease-free survival time. These results suggested that the intracellular ...Continue Reading

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Citations

Sep 4, 2010·Breast Cancer Research and Treatment·Cha Kyong YomHee Sung Kim
Jan 27, 2009·Cancer Metastasis Reviews·Jihe Zhao, Jun-Lin Guan
May 3, 2000·Journal of Hematotherapy & Stem Cell Research·S Sinha, S J Corey
Aug 21, 2010·The American Journal of Pathology·I-Rue LaiTang-Long Shen
Mar 27, 2007·The Journal of Molecular Diagnostics : JMD·Jonathan A SchumacherMegan S Lim
Jul 30, 2011·Cancer·Sebahat OcakPierre P Massion
Mar 29, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey R InfanteLillian L Siu
Sep 2, 2005·British Journal of Cancer·D O WatermannE Stickeler
Apr 28, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Boris GabrielAnnette Hasenburg

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