PMID: 3042748Aug 1, 1988Paper

Role of uhp genes in expression of the Escherichia coli sugar-phosphate transport system

Journal of Bacteriology
L A Weston, R J Kadner


The uhpABCT locus of Escherichia coli is responsible for expression of the sugar-phosphate transport system and its induction by external glucose 6-phosphate. Expression of uhpT-lacZ fusions depended on the function of uhpA, uhpB, and uhpC but not of uhpT. A plasmid carrying only uhpT conferred transport activity in a host strain deleted for the uhp region. Thus, uhpT encodes the polypeptide required for transport function, and the other three uhp genes regulate uhpT transcription. The presence of uhpA at elevated copy number resulted in a substantial increase in uhpT expression. This elevated expression was only about 50% of the level seen in induced haploid cells, and no further increase occurred after addition of inducer. Activation by multicopy uhpA was not affected by the status of uhpC but was decreased in the absence of uhpB, suggesting a role for UhpB in directly activating UhpA. Transcription of uhpA, monitored by expression of a uhpA-lacZ fusion, was not affected by either inducer or the presence of the wild-type uhpA allele. The presence of multiple copies of the uhpT promoter region reduced uhpT expression in strains with uhpA in single copy number but not in those with multiple copies, consistent with competition f...Continue Reading


Dec 2, 1991·International Journal of Cancer. Journal International Du Cancer·C ShalitinE Robinson
Jul 1, 1995·FEMS Microbiology Reviews·K J HellingwerfH V Westerhoff
Mar 11, 2000·European Journal of Biochemistry·G van de WerveA Berteloot
Jan 1, 1993·Journal of Cellular Biochemistry·A J Cozzone
May 27, 2015·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Myu YoshidaKaneyoshi Yamamoto
Nov 20, 2012·Nature·Alline R PachecoVanessa Sperandio
Sep 14, 2002·Infection and Immunity·Holger BassoCarlos A Guzmán
Jul 27, 2000·Journal of Bacteriology·Q Chen, R J Kadner
Jan 17, 2020·Bioscience, Biotechnology, and Biochemistry·Tomoyuki TakeyaHiroya Yurimoto
Jun 26, 2007·Journal of Bacteriology·Elizabeth A HussaKaren L Visick
Nov 17, 2020·Frontiers in Microbiology·Vincent CattoirFrançois Guérin

Related Concepts

Bacterial Proteins
Alkalescens-Dispar Group
Genes, Bacterial
Genes, Regulator
Early Promoters, Genetic
Homologous Sequences, Nucleic Acid
Sugar Phosphates
Transcription, Genetic

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Laryngeal Neoplasms

Laryngeal Neoplasms occur in the Larynx and are typically associated with smoking and alcohol consumption. Discover the latest research on Laryngeal Neoplasms here.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.