Role of ultrasonic shear rate estimation errors in assessing inflammatory response and vascular risk.

Ultrasound in Medicine & Biology
Jean K TsouMichael F Insana

Abstract

Atherosclerotic lesions preferentially originate in arterial regions that experience low wall shear stress (WSS) and reversing flow patterns. Therefore, routinely monitoring arterial WSS may help to identify the potential sites of early atherosclerosis. A new noninvasive ultrasonic method implemented with coded excitation techniques was utilized to improve WSS estimation accuracy and precision by providing high spatial and temporal resolution. WSS measurement errors were quantified in a model system by scanning a linearly varying WSS field (0.3 to 1.9 Pa) within a flow chamber. A 13-bit optimal code (Opt) was found to be most effective in reducing bias and standard deviation in WSS estimates down to approximately 10% and approximately 8%. The measurement errors slowly increased with input WSS for all imaging pulses. The expression of endothelial cellular adhesion molecules vascular cell adhesion molecule-1 (VCAM-1) and endothelial-leukocyte adhesion molecule-1 (E-selectin) was investigated over a similar shear range (0 to 1.6 Pa) to study the impact of relating shear-mediated cellular adhesion molecule (CAM) expression to inaccuracies in WSS measurements. We quantified this influence as the prediction error, which accounts for ...Continue Reading

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Citations

Oct 11, 2016·Lab on a Chip·Citsabehsan DevendranAdrian Neild
Jun 11, 2016·Physics in Medicine and Biology·M FonsecaB T Cox
Jan 24, 2018·Microfluidics and Nanofluidics·Yusheng BianTony Jun Huang
Aug 4, 2021·The Journal of the Acoustical Society of America·Mehrshad Rezadoost DezfuliMajid Ghassemi

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