Role of unilateral adrenalectomy in bilateral adrenal hyperplasias with Cushing's syndrome.

Best Practice & Research. Clinical Endocrinology & Metabolism
Léamarie Meloche-DumasAndré Lacroix

Abstract

Primary bilateral adrenocortical hyperplasias are rare forms of pituitary ACTH-independent Cushing's syndrome (CS). They are divided between primary bilateral macronodular adrenal hyperplasia (PBMAH) and micronodular adrenal hyperplasia (MiBAH), which is subdivided in primary pigmented nodular adrenocortical disease (PPNAD) and isolated micronodular adrenocortical disease (i-MAD). One of the most debated aspects surrounding these entities is their most appropriate therapy. Although bilateral adrenalectomy (BA) has previously been the most utilized therapy for patients with overt CS, recent studies have indicated that unilateral adrenalectomy (UA) can be effective in patients with PBMAH and some with MiBAH with fewer long-term side effects. Medical therapies can also be used for bridging to surgery or rarely in the long-term for these patients. We review the various degrees of CS resulting from PBMAH and MiBAH, with a special focus on their respective therapies including UA, taking into account the recent pathophysiological and genetics findings.

References

Oct 25, 1996·Deutsche medizinische Wochenschrift·K AndingH P Neumann
Apr 1, 1997·The Journal of Clinical Endocrinology and Metabolism·N J SarlisC A Stratakis
Nov 14, 1997·The New England Journal of Medicine·A LacroixP Hamet
Aug 7, 1998·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·C A Stratakis, L S Kirschner
Aug 12, 1999·The Journal of Clinical Endocrinology and Metabolism·N N'DiayeA Lacroix
Nov 24, 1999·The New England Journal of Medicine·A LacroixJ M Boutin
Jan 10, 2003·The Journal of Clinical Endocrinology and Metabolism·Mark O GoodarziAndre J Van Herle
Dec 24, 2003·Surgical Endoscopy·F JägerT Junginger
Apr 27, 2005·Endocrinology and Metabolism Clinics of North America·André Lacroix, Isabelle Bourdeau
Dec 7, 2007·European Journal of Endocrinology·N M AlbigerC Scaroni
Jan 25, 2008·World Journal of Surgery·Maurizio IacoboneGennaro Favia
Jun 9, 2009·Best Practice & Research. Clinical Endocrinology & Metabolism·André Lacroix
Jan 26, 2010·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·R GuanàF Canavese
Jan 26, 2011·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·V PreumontD Maiter
Sep 15, 2011·International Journal of Urology : Official Journal of the Japanese Urological Association·Yoshihide KawasakiYoichi Arai
Sep 22, 2011·Journal of Pediatric Endocrinology & Metabolism : JPEM·Malgorzata Kumorowicz-CzochJerzy Starzyk
Nov 8, 2011·The Journal of Clinical Endocrinology and Metabolism·Guilherme Asmar AlencarBerenice Bilharinho Mendonca
Nov 25, 2011·The Journal of Clinical Endocrinology and Metabolism·João AnselmoConstantine A Stratakis
Feb 22, 2013·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Adam MaghrabiTipu Saleem
Jun 12, 2013·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Sandeep AggarwalVrishketan Sethi
Aug 21, 2013·The Journal of Clinical Endocrinology and Metabolism·Katrin RitzelMartin Reincke
Nov 29, 2013·The New England Journal of Medicine·Guillaume AssiéJérôme Bertherat
Nov 29, 2013·The New England Journal of Medicine·Estelle LouisetHervé Lefebvre
Apr 18, 2014·Current Opinion in Endocrinology, Diabetes, and Obesity·Agostino De VenanziAndré Lacroix

❮ Previous
Next ❯

Citations

Oct 12, 2021·Experimental and Therapeutic Medicine·Florica SandruDiana Loreta Paun

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Best Practice & Research. Clinical Endocrinology & Metabolism
Isabelle BourdeauAndré Lacroix
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
Annabel Berthon, Jérôme Bertherat
Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
Mohammad Sheikh-AhmadLeonard Saiegh
© 2022 Meta ULC. All rights reserved