PMID: 8971987Nov 1, 1996Paper

Role of vagal lung C-fibres in the cardiorespiratory effects of capsaicin in monkeys

Respiration Physiology
K Ravi, M Singh

Abstract

Apnoea, bradycardia and hypotension were elicited by right atrial injections of capsaicin in anaesthetized monkeys. At the threshold dose (2.5 +/- 0.3 microgram/kg), tachypnoea was elicited (latency 1.6 +/- 0.2 s) which got replaced by apnoea with higher doses of capsaicin. These responses persisted (1) after cooling the cervical vagi to 6-8 degrees C, and (2) after instilling xylocaine into the pericardial sac. Tachypnoea and apnoea were elicited after bilateral cervical vagotomy also, but only with higher doses and after a longer latency (5.0 +/- 0.3 s). Right atrial injection of capsaicin and insufflation of halothane stimulated vagal pulmonary C-fibre receptors with a latency of 1.7 +/- 0.7 s and 0.2 +/- 0.1 s, respectively. Tachypnoea/apnoea, bradycardia and hypotension were elicited by left atrial injection of capsaicin also (threshold dose: 5.0 +/- 1.2 micrograms/kg). The respiratory responses persisted (1) after instilling xylocaine into the pericardial sac, and (2) after bilateral cervical vagotomy suggesting that they were due to stimulation of non-cardiac receptors with sympathetic afferents. It is concluded that the initial respiratory responses elicited by right atrial injection of capsaicin were due to stimulation...Continue Reading

References

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Citations

Mar 10, 2001·Respiration Physiology·L Y Lee, T E Pisarri
Sep 10, 2013·Indian Journal of Pharmacology·Abhaya DuttaShripad B Deshpande
Jul 1, 2008·Respiratory Physiology & Neurobiology·Lu-Yuan Lee
Apr 1, 2006·Journal of Applied Physiology·Rurong Wang, Fadi Xu
Aug 20, 2005·Journal of Applied Physiology·Michael R Van ScottHoward W Stallings
Dec 17, 2002·Journal of Applied Physiology·Fadi XuLu-Yuan Lee

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