PMID: 7030748Jan 1, 1981Paper

Role of various vasodepressor systems in the acute hypotensive effect of captopril in man

European Journal of Clinical Pharmacology
P LijnenA Amery

Abstract

The acute hypotensive effect of captopril 25 mg was investigated in 26 hypertensive patients (11 with essential and 15 with renal arterial disease). Intra-arterial blood pressure was recorded continuously and arterial blood was sampled for renin, angiotensin I and II, aldosterone, kininase II, catecholamines and prostaglandins. Captopril led to an increase in plasma renin activity, active and total plasma renin concentration and angiotensin I, a decrease in plasma kininase II activity, angiotensin II, aldosterone, prostaglandins E2 and F2 alpha and no change in plasma (nor) adrenaline, dopamine and inactive renin concentration. The hypotensive effect of captopril was related to the changes in plasma angiotensin II level and inversely to the changes in prostaglandin E2; the correlation coefficients were low, respectively 0.61 and -0.44. It is likely that the acute hypotensive effect of captopril to some extent is related to changes in plasma angiotensin II and in prostaglandins E2 and F2 alpha. There is no evidence for a role of the adrenergic systems in the hypotensive response.

References

Nov 1, 1979·Journal of Cardiovascular Pharmacology·P J LijnenA F De Schaepdryver
Jan 1, 1978·Proceedings of the Society for Experimental Biology and Medicine·V S MurthyM E Goldberg
Sep 1, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·P J LijnenF H Katz
Jul 1, 1978·Prostaglandins and Medicine·S Y TanP J Mulrow
Jan 1, 1979·British Journal of Clinical Pharmacology·H R BrunnerI Gavras
Mar 15, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·P LijnenP Corvol
Jul 1, 1972·Prostaglandins·R M ZusmanH R Behrman
Jan 1, 1969·European Journal of Pharmacology·S M KarimK Hillier

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Citations

Jan 1, 1982·Clinical and Experimental Hypertension. Part A, Theory and Practice·A P NiarchosJ H Laragh
Jan 1, 1981·European Journal of Clinical Pharmacology·U Bergman, B E Wiholm
Jul 16, 2004·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Sandra KnappGianfranco Novarino
Jan 1, 1984·Acta Pharmacologica Et Toxicologica·K DelinH Herlitz
Jan 1, 1984·The Journal of Pharmacy and Pharmacology·P J ChiuA Barnett

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