Role of vascular nitric oxide in physiological and pathological conditions

Pharmacology & Therapeutics
J Marín, M A Rodríguez-Martínez

Abstract

This review describes the ability of certain diseases, such as essential hypertension, atherosclerosis, angina, and vasospasm, to reduce vascular nitric oxide (NO) formation or to increase its metabolism. In contrast, others, such as hypotension, sepsis, stroke, myocardial depression, and inflammatory responses, increase NO synthesis. The mechanism implicated in the changes in the formation and metabolism of NO are described. To prevent or treat these pathological processes, in which a deficiency in vascular NO formation plays a causative role, NO may be provided through methods such as direct NO administration or indirect NO supply through either NO donors or L-arginine, which facilitates NO formation.

References

Oct 1, 1979·Jikken dobutsu. Experimental animals·H Tanase
Jan 1, 1992·Journal of Cardiovascular Pharmacology·C PeiróJ Marín
Jan 1, 1992·Journal of Cardiovascular Pharmacology·K HishikawaT Saruta
Jan 1, 1992·Journal of Cardiovascular Pharmacology·P VallanceS Moncada
Dec 7, 1992·Neuroscience Letters·N J DunL F Tseng
Jan 1, 1992·Trends in Pharmacological Sciences·T McCall, P Vallance
May 1, 1992·Journal of Medicinal Chemistry·A M Doherty
Jul 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S LamasT Michel
Jul 28, 1992·Biochemistry·K A White, M A Marletta
Aug 1, 1992·The Journal of Experimental Medicine·H J ChoC Nathan
Oct 1, 1992·The Journal of Clinical Investigation·M A CreagerJ P Cooke
Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J S StamlerJ Loscalzo
Sep 1, 1992·The Journal of Clinical Investigation·J P CookeM E Billingham
Jan 1, 1992·Life Sciences·P KarczewskiJ Schrader
Sep 16, 1992·Biochemical and Biophysical Research Communications·J L BoucherD Mansuy
Aug 1, 1991·Clinical Science·A HalkinJ M Ritter
Aug 15, 1991·Archives of Biochemistry and Biophysics·J KannerR Granit
Sep 1, 1991·American Journal of Hypertension·W Auch-Schwelk, P M Vanhoutte
Dec 31, 1991·Biochemical and Biophysical Research Communications·G M RubanyiL H Botelho
Sep 21, 1991·Lancet·M P GlauserJ Cohen
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D S Bredt, S H Snyder

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Citations

Nov 17, 2001·European Journal of Pharmacology·B J De WittP J Kadowitz
Jul 28, 1999·European Journal of Pharmacology·M C Koss
Dec 18, 2001·Pharmacology & Therapeutics·F FeihlL Liaudet
Sep 24, 2002·Pharmacology & Therapeutics·B J Nevin, K J Broadley
May 19, 2000·Experimental Gerontology·J Marín, M A Rodríguez-Martínez
Aug 15, 2002·Nitric Oxide : Biology and Chemistry·Kelly Fabiane Santos RicardoMarta Helena Krieger
Jun 24, 2000·British Journal of Pharmacology·S MarxR E Garfield
Feb 15, 2001·Veterinary Surgery : VS·L M Howe, H W Boothe
Mar 4, 2003·Journal of Cellular and Molecular Medicine·I Haulica
Sep 24, 2013·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Leônidas das Graças Mendes-JuniorValdir de Andrade Braga
Jul 24, 2010·Journal of Ophthalmology·Ryoichi AritaTatsuro Ishibashi
Dec 26, 2001·American Journal of Respiratory and Critical Care Medicine·K J SullivanJ J Lima
Jun 13, 2013·Pharmacology & Therapeutics·Hoshang Farhad, Venkatesh L Murthy
Sep 13, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Jia-Yin FuQiang Xia
Jun 15, 2010·European Journal of Pharmacology·Aline C PereiraAna M de Oliveira
Nov 7, 2009·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ling-Bo QianQiang Xia
Jun 25, 2009·European Journal of Pharmacology·Bi-hui JinQiang Xia
Mar 27, 2007·Free Radical Biology & Medicine·Enika Nagababu, Joseph M Rifkind
Jul 6, 2004·Clinical Physiology and Functional Imaging·V V ZinchukM A Lis
Aug 28, 2003·Journal of the European Academy of Dermatology and Venereology : JEADV·M U SenturkA Yesilkaya
Jul 16, 2013·Journal of Biomedical Materials Research. Part a·Jingan LiNan Huang
Nov 25, 2006·Nitric Oxide : Biology and Chemistry·P G ZanichelliD W Franco
May 7, 2005·Nitric Oxide : Biology and Chemistry·M del Carmen MartínMercedes Ferrer

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