PMID: 9170008May 1, 1997Paper

Role of vasopressin in essential hypertension: racial differences

Journal of Hypertension
G BakrisH Gavras

Abstract

Arginine vasopressin (AVP), in addition to being an antidiuretic hormone, might also have pressor effects relevant to the maintenance of hypertension. Results from several experimental and clinical studies suggested that the pressor function of AVP is more important in low-renin hypertension and in the salt-loaded state and that it might be further maximized under sympathetic suppression. To assess whether selective vasopressin receptor inhibition lowers the blood pressure in a racially diverse group of low-renin hypertensive subjects. Thirty-nine hypertensive subjects (16 Caucasian, 23 African-American) eating a 200 mmol/day sodium diet were administered a single intravenous dose of a selective vasopressin receptor antagonist and their blood pressure was monitored constantly for the ensuing 3 h. The protocol was repeated 3 days later after treatment with a single oral dose of 0.4 mg clonidine. Of these patients, 54% had their blood sampled for determination of hormone profiles. African-Americans with hypertension had higher baseline plasma AVP levels than did Caucasians (1.13 +/- 0.05 versus 0.37 +/- 0.06 pg/ml, respectively, P < 0.05), and lower plasma renin activity (0.34 +/- 0.07 versus 1.03 +/- 0.08 ng/ml per h, respective...Continue Reading

References

Jun 1, 1990·Journal of the American Geriatrics Society·M BursztynH Gavras
Jan 1, 1986·Journal of Cardiovascular Pharmacology·K H Berecek
Jan 1, 1987·Clinical and Experimental Hypertension. Part A, Theory and Practice·N Papadoliopoulou-DiamandopoulouH Gavras
Jan 1, 1986·Acta Medica Scandinavica·E B PedersenO O Thomsen
Apr 1, 1972·Kidney International·J E SealeyJ H Laragh
Mar 1, 1968·The Journal of Clinical Investigation·D A Fisher
Oct 1, 1983·Physiological Reviews·A H Sklar, R W Schrier
Aug 1, 1980·Pflügers Archiv : European journal of physiology·F T LaRochelleP Stern
Aug 22, 1980·Science·P HatzinikolaouI Gavras
Jul 22, 1993·Annals of the New York Academy of Sciences·R B De PaulaH Gavras

❮ Previous
Next ❯

Citations

Jan 5, 2008·Heart Failure Reviews·Laurence BodineauCatherine Llorens-Cortes
Sep 12, 2000·Current Hypertension Reports·P A JoseR A Felder
Mar 8, 2005·Current Hypertension Reports·Annabelle Reaux-Le GoazigoCatherine Llorens-Cortes
Mar 27, 2009·Nature Reviews. Nephrology·Tevfik Ecder, Robert W Schrier
Feb 26, 2000·Acta Physiologica Scandinavica·J A SchaferD Sun
Feb 26, 2000·Acta Physiologica Scandinavica·R A FelderP A Jose
Jun 16, 2009·Seminars in Dialysis·Aliza M Thompson, Juan A Oliver
Jun 25, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael L HancockJ Howard Pratt
Nov 23, 2007·Journal of the American Society of Nephrology : JASN·Xiaofang WangVicente E Torres
Apr 13, 2007·Drugs·Farhan AliJalal K Ghali
Jan 1, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Edyta Tenderenda-BanasiukMarlena Waszkiewicz-Stojda
May 12, 2004·Proceedings of the National Academy of Sciences of the United States of America·Marie-Claude Fournie-ZaluskiCatherine Llorens-Cortes
May 5, 2000·Experimental Physiology·L M BurrellL C Balding
Mar 24, 2006·Autonomic & Autacoid Pharmacology·J O Streefkerk, P A van Zwieten
Jan 28, 2010·Acta Clinica Belgica·L D KolaJ M Krzesinski
Jan 16, 2008·Journal of Neuroendocrinology·C Llorens-Cortes, C Kordon
Oct 21, 2003·Autonomic & Autacoid Pharmacology·J O StreefkerkP A van Zwieten
Jul 5, 2008·European Journal of Pharmacology·Joseph W GunnetBruce P Damiano
Nov 26, 2003·Journal of Cardiovascular Pharmacology·Jörn O StreefkerkPieter A van Zwieten
May 9, 2018·European Heart Journal. Acute Cardiovascular Care·Neil BeriAlan Maisel
Jun 25, 2002·Journal of Human Hypertension·F Elijovich, C L Laffer
Feb 18, 2004·Hypertension·Abraham AvivAlan Weder
Oct 26, 2018·Journal of Nephrology·Masahiko OguroKenmei Takaichi
Dec 19, 2008·Cardiology in Review·Gerard Oghlakian, Marc Klapholz
Jul 14, 2009·American Journal of Human Biology : the Official Journal of the Human Biology Council·Lillian Gleiberman
Sep 23, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Julie PeruccaLise Bankir
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Lise BankirMyron H Weinberger
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Friedrich C Luft
Feb 27, 2013·Nature Reviews. Nephrology·Lise BankirEberhard Ritz
Jun 13, 2003·American Journal of Physiology. Cell Physiology·Richard BouleyDennis A Ausiello
Sep 17, 2013·Journal of Cellular Physiology·Adolfo E CuadraJosé R Lemos
May 23, 2002·Journal of Hypertension·Jörn O StreefkerkPieter A van Zwieten
Sep 6, 2015·The European Journal of Neuroscience·Su Young HanColin H Brown
Aug 18, 2020·Expert Opinion on Drug Safety·Steven G Chrysant, George S Chrysant
Jul 12, 2002·American Journal of Physiology. Renal Physiology·James A Schafer
Nov 4, 2004·Journal of Receptor and Signal Transduction Research·Zhiwei YangPedro A Jose
Apr 30, 2017·Current Hypertension Reports·Masha Prager-KhoutorskyCharles W Bourque
Jun 24, 2017·Clinical Hypertension·Baris Afsar
Jun 21, 2020·Clinical Journal of the American Society of Nephrology : CJASN·Anna L ZismanElaine M Worcester

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.