Role of vasopressin in neurocardiogenic responses to hemorrhage in conscious rats

Hypertension
Y ImaiK Abe

Abstract

Vasovagal reflexes, such as hypotension and bradycardia, are induced by rapid hemorrhage and mimic neurocardiogenic reflexes in mammals. We examined the role of vasopressin in the neurocardiogenic responses to mild, rapid hemorrhage (1 mL/100 g for 30 seconds) and severe hemorrhage (1 mL/100 g body wt for 30 seconds repeated three times at 11-minute intervals) in homozygous Brattleboro and Long-Evans rats. Mild, rapid hemorrhage induced severe bradycardia and hypotension only in Long-Evans rats. Exogenous vasopressin (1.85 pmol/kg per minute for 1 hour) restored both the bradycardic and hypotensive responses in Brattleboro rats. DDAVP, a vasopressin V2-receptor agonist (0.19 pmol/kg per minute for 24 hours), did not affect the cardiovascular responses to hemorrhage in Brattleboro rats, although it maintained urine production within normal limits. However, OPC-31260 (21.6 mumol/kg IV), a vasopressin V2-receptor antagonist, attenuated both the hypotensive and bradycardic responses to hemorrhage in Long-Evans rats. A vasopressin V1-receptor antagonist attenuated bradycardia and delayed the recovery of arterial pressure after hemorrhage but did not affect the hypotension that occurred immediately after hemorrhage in Long-Evans rats...Continue Reading

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Citations

Feb 28, 2002·British Journal of Pharmacology·Beatriz PalaciosCatherine C Y Pang
Oct 18, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Lusha XiangRobert Hester
May 27, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Naoyuki TakahashiAtsushi Hirayama
Jun 2, 2009·Autonomic Neuroscience : Basic & Clinical·Karen PorterLinda F Hayward
Sep 24, 2019·Current Neuropharmacology·Nina Japundžić-ŽigonDavid Murphy
Jun 3, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andre S MecawiJose Antunes-Rodrigues
May 18, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Bojana SavićNina Japundžić-Žigon

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