PMID: 6404501Mar 7, 1983Paper

Role of ventral mesencephalic reticular formation and related noradrenergic and serotonergic bundles in turning behaviour as investigated by means of kainate, 6-hydroxydopamine and 5,7-dihydroxytryptamine lesions

Brain Research
M L PorcedduG Di Chiara

Abstract

A unilateral kainate (KA) infusion (2 x 0.15 micrograms, 2 x 0.25 micrograms) in the ventral mesencephalic reticular formation (MRF) resulted in spontaneous contraversive turning lasting only a few days. Upon challenge with apomorphine (0.5 mg/kg s.c.) or amphetamine (5 mg/kg i.p.) the contraversive turning could be reinstated. The incidence, as well as the intensity, of the drug-induced response decreased over the 45 days of observation. KA infused in the ventral MRF induced typical lesions after doses of 2 x 0.15 micrograms but resulted in demyelination after 2 x 0.25 micrograms. These lesions failed to reduce noradrenaline (NA), serotonin (5 HT) or dopamine (DA) in various forebrain areas. Unilateral lesion of ascending NA projections by 6-OHDA infusion (4 micrograms) within the NA bundles coursing in the mesencephalon or near the locus coeruleus, failed to induce motor asymmetries. Unilateral selective lesion of the ventral NA bundle by local 6-OHDA (2 micrograms) infusion also failed to induce motor asymmetries, either spontaneously or in response to dopaminergic drugs. Unilateral lesion of ascending 5-HT projections by the tegmental infusion of 5,7-dihydroxytryptamine (10 micrograms) also failed to induce motor asymmetrie...Continue Reading

References

May 23, 1975·Brain Research·B Srebro, S A Lorens
Jan 1, 1971·Acta Physiologica Scandinavica. Supplementum·U Ungerstedt
Jan 1, 1971·Acta Physiologica Scandinavica. Supplementum·U Ungerstedt
Jul 1, 1974·The Journal of Comparative Neurology·L C ConradD W Pfaff
Oct 1, 1969·The Journal of Comparative Neurology·H A Waldron, D G Gwyn
Jan 10, 1982·The Journal of Comparative Neurology·R B Veazey, C M Severin
Apr 8, 1982·Brain Research·G Di ChiaraM L Porceddu
Dec 1, 1980·Pharmacology, Biochemistry, and Behavior·P Slater
Mar 15, 1980·The Journal of Comparative Neurology·R B Veazey, C M Severin
Mar 15, 1980·The Journal of Comparative Neurology·R B Veazey, C M Severin

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Citations

Dec 17, 2009·Journal of Neural Transmission·Ana C BarcelóJorge Horacio Pazo
Jan 17, 2004·The European Journal of Neuroscience·J E Belforte, J H Pazo
Feb 1, 1984·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·E G McGeerP L McGeer

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