Role of vertical transmission of Toxoplasma gondii in prevalence of infection

Expert Review of Anti-infective Therapy
G Hide

Abstract

The parasite, Toxoplasma gondii, is a highly successful pathogen that infects around 30% of the global human population. Additionally, it is able to infect all warm blooded animals with high prevalence. This is surprising as it is a parasite of the cat and can only complete its full sexual cycle in that host. This review examines the important key routes of transmission: infective oocysts from the cat, ingestion of raw infected tissue and vertical transmission. The latter route of transmission has traditionally been thought to be rare. In this review, this assumption is examined and discussed in the light of the current literature. The available evidence points to the possibility that vertical transmission occurs frequently in natural populations of mice however the evidence in sheep is currently ambivalent and controversial. In humans, the situation appears as though vertical transmission may be rare although there is still much that is unexplained.

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Citations

Oct 30, 2016·Transactions of the Royal Society of Tropical Medicine and Hygiene·Sameena Z H HaqGeoff Hide
Apr 14, 2017·Clinical Microbiology Reviews·Mohamed-Ali HakimiL David Sibley
Dec 12, 2018·Antimicrobial Agents and Chemotherapy·Qi-Wei ChenJian-Ping Chen
Jan 7, 2020·Foodborne Pathogens and Disease·Ignacio Gisbert AlgabaStephane De Craeye
Jun 17, 2020·BMC Infectious Diseases·Fei XuYonghua Zhou
Oct 22, 2019·Parasitology International·Baldorj PagmadulamYoshifumi Nishikawa
Dec 17, 2019·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Lokman GalalAurélien Mercier
Jun 15, 2021·Frontiers in Cell and Developmental Biology·Lijie YaoHongjuan Peng
Jul 31, 2018·ACS Infectious Diseases·Joshua B RadkeL David Sibley

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