Role of vinculin in cellular mechanotransduction

Cell Biology International
Wolfgang H Goldmann

Abstract

Cell-matrix adhesion and cell-cell contacts are essential for the metabolism, protein synthesis, survival, and cancer metastasis of cells. Major transmembrane receptors are the integrins, which are responsible for cell-matrix adhesions, and the cadherins, which are important for cell-cell adhesions. Adherent cells anchor via focal adhesion proteins to the extracellular matrix, whereas cell-cell contacts connect via focal adherens junction proteins. The temporal formation of these connections is greatly strengthened either through externally applied stresses on the cell or by myosin-driven cell contractility. The mechanism by which protein(s) within these connections sense, transmit, and respond to mechanochemical signaling is currently strongly debated and various candidates have been named. Vinculin has been described as one of the key players in cell-matrix and cell-cell adhesions that build a strong physical connection for transmitting forces between the cytoskeleton, the extracellular matrix, and cell-cell connections.

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Citations

Nov 10, 2013·PloS One·Thomas SchluckChristof M Aegerter
Apr 27, 2018·Cell Biology International·Wolfgang H Goldmann
May 16, 2018·Biomedical Materials·Christopher D JohnsonRyan J Gilbert
Feb 23, 2017·Journal of Cell Science·Peta M BradburyGeraldine M O'Neill
Apr 6, 2019·The Journal of International Medical Research·Qiuli YuZhiyong Yang
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May 27, 2021·Molecular Biology of the Cell·Stefano Sala, Patrick W Oakes

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