Role of viruses in type I diabetes

Seminars in Immunology
M G von HerrathM B Oldstone

Abstract

Viral infections frequently elicit strong cellular and humoral immune responses. This bears the inherent danger of co-activating autoreactive lymphocytes, either through bystander activation by cytokines or through direct sharing of conformational determinants between self and virus (mimicry). Autoimmune diseases could then result, even after clearance of the viral infection, if enough autoreactive cells are activated. Alternatively, viral infection of antigen presenting cells can locally enhance inflammation and drive autoreactive lymphocytes. Evidence for these mechanisms, as well as emerging therapeutic concepts, will be discussed.

Citations

Dec 2, 2004·Nature Reviews. Immunology·Bart O RoepMatthias von Herrath
Nov 6, 2009·Proceedings of the National Academy of Sciences of the United States of America·Marshall S HorwitzMichael B A Oldstone
Feb 4, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity·Steven C PinoRita Bortell
Sep 7, 2006·The Journal of Clinical Investigation·Marco Colonna
Sep 30, 1999·Environmental Health Perspectives·M R Kraine, R M Tisch
Dec 15, 2012·Critical Reviews in Immunology·Galina PetrovaJack Gorski
Aug 20, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hiroaki MoriyamaGeorge S Eisenbarth
Dec 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Shannon J TurleyChristophe Benoist
Jan 6, 2009·Annals of the New York Academy of Sciences·Rita BortellAldo A Rossini
Feb 18, 2005·Microbes and Infection·Alison P Galvani, John Novembre
Jan 1, 2004·The Journal of Clinical Investigation·Urs ChristenMatthias G von Herrath
Jan 17, 2013·The American Journal of Pathology·Fnu NagajyothiHerbert B Tanowitz
Apr 13, 2000·Baillière's Best Practice & Research. Clinical Endocrinology & Metabolism·T A ChowdhuryA H Barnett
Apr 1, 2004·Endocrinology and Metabolism Clinics of North America·Urs ChristenMatthias G von Herrath
May 29, 2003·Human Immunology·Akito TsutsumiTakayuki Sumida
Nov 3, 2004·Autoimmunity·Urs Christen, Matthias G von Herrath
Jun 18, 2005·American Journal of Epidemiology·Fotini K Kavvoura, John P A Ioannidis
May 7, 2003·Gene Therapy·R BottinoN Giannoukakis
Feb 20, 2003·Diabetes/metabolism Research and Reviews·Hee-Sook Jun, Ji-Won Yoon
Dec 6, 2003·Pediatric Diabetes·Joel N Hirschhorn
Dec 26, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shawn WinerH-Michael Dosch
Jun 30, 2000·Clinical Immunology : the Official Journal of the Clinical Immunology Society·V Bonnevie-NielsenT Dyrberg

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