Role of vitamin D in adipose tissue in obese rats programmed by early weaning and post diet calcium

Molecular Nutrition & Food Research
J L NobreElaine de Oliveira

Abstract

Early weaning (EW) is associated with an impairment of offspring development and leads to overweight and higher 25-hydroxyvitamin D (25(OH)D) levels in adulthood, which can be corrected by calcium supplementation, potentially via vitamin D regulation of adipogenesis. We examined vitamin D status in adipose tissue in EW obese rats, treated with calcium. Dams were separated into: EW- dams were wrapped with a bandage to interrupt lactation (last 3 days), and C- pups with free access to milk. At PN120, EW pups were divided in: EW- standard diet, and EWCa- calcium supplementation (10g of calcium carbonate/kg of chow). On PN21, EW group has hypocalcemia. On PN180, EW group showed lower intestinal calbidin, higher adiposity and 25(OH)D. In adipose tissue, Cyp27b1/1alpha-Hydroxylase, C/EBPB, PPARγ, IL6, TNF-A and MCP1 were increased, while VDR and IL10 were decreased. Calcium increased calbidin, VDR and prevented adipose tissue dysfunction. EW group has a long-term effect of vitamin D on adipocyte, contributing to pro-inflammatory status and obesity. Thus we propose that in obese rat adipocytes, 1,25(OH)2 D down-regulates VDR, resulting in vitamin D resistance, characterized by higher Cyp27b1/1α-Hydroxylase and adipogenesis. Calcium th...Continue Reading

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Citations

Apr 25, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·E P S ConceiçãoP C Lisboa
Jun 22, 2016·The Journal of Endocrinology·E P S ConceiçãoP C Lisboa
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May 19, 2021·The Journal of Steroid Biochemistry and Molecular Biology·Maria OczkowiczAnna Steg
Oct 15, 2019·Journal of Agricultural and Food Chemistry·Pengbo CuiNa Sun

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