Role of VMH ketone bodies in adjusting caloric intake to increased dietary fat content in DIO and DR rats

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Christelle Le FollBarry E Levin

Abstract

The objective of this study was to determine the potential role of astrocyte-derived ketone bodies in regulating the early changes in caloric intake of diet induced-obese (DIO) versus diet-resistant (DR) rats fed a 31.5% fat high-energy (HE) diet. After 3 days on chow or HE diet, DR and DIO rats were assessed for their ventromedial hypothalamic (VMH) ketone bodies levels and neuronal ventromedial hypothalamic nucleus (VMN) sensing using microdialysis coupled to continuous food intake monitoring and calcium imaging in dissociated neurons, respectively. DIO rats ate more than DR rats over 3 days of HE diet intake. On day 3 of HE diet intake, DR rats reduced their caloric intake while DIO rats remained hyperphagic. Local VMH astrocyte ketone bodies production was similar between DR and DIO rats during the first 6 h after dark onset feeding but inhibiting VMH ketone body production in DR rats on day 3 transiently returned their intake of HE diet to the level of DIO rats consuming HE diet. In addition, dissociated VMN neurons from DIO and DR rats were equally sensitive to the largely excitatory effects of β-hydroxybutyrate. Thus while DR rats respond to increased VMH ketone levels by decreasing their intake after 3 days of HE diet, ...Continue Reading

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Citations

Mar 24, 2016·Progress in Neurobiology·Julie A ChowenJesús Argente
Sep 30, 2015·Molecular and Cellular Endocrinology·Christophe MagnanSerge Luquet
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Apr 29, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christelle Le Foll, Barry E Levin
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Jun 6, 2017·Neurochemistry International·Scott J Koppel, Russell H Swerdlow
Apr 6, 2021·Frontiers in Endocrinology·Olga Barca-Mayo, Miguel López

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