Role of YadA in arthritogenicity of Yersinia enterocolitica serotype O:8: experimental studies with rats.

Infection and Immunity
C Gripenberg-LercheP Toivanen

Abstract

Outer membrane protein YadA, the Yersinia adhesin, is one of the plasmid-encoded virulence factors of yersiniae. To evaluate the role of YadA in the pathogenesis of reactive arthritis experimentally, we used YadA- strain YeO8-116, a kanamycin GenBlock insertion mutant derived from Yersinia enterocolitica O:8 wild-type strain 8081. As control strains, a plasmid-cured derivative (8081-c) of 8081 and a YopH- mutant (8081-yoph) were used. In addition, YeO8-116, with the yadA mutation transcomplemented with plasmid pMW10, was used. YeO8-116 induced arthritis to a considerably lesser extent than did wild-type strain 8081 when inoculated intravenously into Lewis rats. In rats surviving for over 14 days after the bacterial inoculation, the arthritis incidences were 6% (4 of 72) among those inoculated with the yadA mutant and 51% (33 of 65) among those inoculated with wild-type strain 8081. When the yadA gene was transcomplemented back to YeO8-116, YeO8-116/pMW10 induced arthritis in 47% (9 of 19) of the inoculated rats. Plasmid-cured strain 8081-c did not induce arthritis in any of the 24 inoculated rats, whereas YopH- mutant 8081-yoph induced arthritis in 20% (5 of 25) of the rats inoculated. Although the 50% lethal dose of YeO8-116 w...Continue Reading

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Citations

Apr 1, 1997·Annals of Medicine·K Granfors
Jul 9, 2008·Applied and Environmental Microbiology·Tae-Jong KimGlenn M Young
Jul 16, 2002·Current Opinion in Rheumatology·César Pacheco-TenaRobert D Inman
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Feb 21, 2006·Proceedings of the National Academy of Sciences of the United States of America·Tanja Heise, Petra Dersch
Nov 24, 2004·Infection and Immunity·Yvonne SchmidErwin Bohn
Jan 11, 2013·Memórias do Instituto Oswaldo Cruz·André Alves DiasMaria Cristina Vidal Pessolani
Nov 8, 2011·Molecular Microbiology·Elise PintaMikael Skurnik
Sep 18, 2017·Rheumatology International·Riitta TuompoMarjatta Leirisalo-Repo
Aug 6, 1999·FEMS Immunology and Medical Microbiology·N MarkovaK Veleva
Oct 8, 1997·Infection and Immunity·L B CorbeilT J Beveridge

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