Role of ZnS Nanoparticles on Endoplasmic Reticulum Stress-mediated Apoptosis in Retinal Pigment Epithelial Cells

Biological Trace Element Research
Bose KarthikeyanThandavarayan Kathiresan

Abstract

Age-related macular degeneration (AMD) is the leading cause for irreversible visual impairment affecting 30-50 million individuals every year. Oxidative stress and endoplasmic reticulum stress have been identified as crucial factors for the pathogenesis of AMD. Current treatments do not focus on underlying stimuli responsible for the disease like AMD. Zinc is an important trace metal in retina and its deficiency leads to AMD. Recent studies on zinc sulphide nanoparticles (ZnS-NPs) are gaining attention in the field of physical and biological research. In this present study, in investigating the role of ZnS-NPs on hydrogen peroxide and thapsigargin-treated primary mice retinal pigment epithelial (MRPE) cells, we synthesized ZnS-NPs and characterized using atomic force microscope (AFM) and SEM-EDX. The ZnS-NPs abrogate the primary MRPE cell death through inhibition of oxidative stress-induced reactive oxygen species production and cell permeability. Oxidant molecules hydrogen peroxide and thapsigargin alter unfolded protein response such as glucose-regulated protein 78 (GRP78) and C/EBP homology protein (CHOP) expressions, whereas ZnS-NPs-pre-treated primary MRPE cells downregulated the overexpression of such proteins. The expres...Continue Reading

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Citations

Nov 3, 2015·Artificial Cells, Nanomedicine, and Biotechnology·Karthikeyan BoseThandavarayan Kathiresan
Oct 26, 2016·Apoptosis : an International Journal on Programmed Cell Death·Bose KarthikeyanThandavarayan Kathiresan
Jul 12, 2019·Journal of Applied Toxicology : JAT·Na Liu, Meng Tang
Jul 6, 2019·Plant Physiology and Biochemistry : PPB·Mala ThapaAbhishek Mukherjee

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