Roles and Mechanisms of Human Cathelicidin LL-37 in Cancer

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Xi ChenLihua Liang

Abstract

LL-37, the C-terminal peptide of human cathelicidin antimicrobial peptide (CAMP, hCAP18), reportedly increases resistance to microbial invasion and exerts important physiological functions in chemotaxis, promotion of wound closure, and angiogenesis. Accumulating evidence indicates that LL-37 also plays a significant role in human cancer. LL-37 induces tumorigenic effects in cancers of the ovary, lung, breast, prostate, pancreas, as well as in malignant melanoma and skin squamous cell carcinoma. In contrast, LL-37 displays an anti-cancer effect in colon cancer, gastric cancer, hematologic malignancy and oral squamous cell carcinoma. Mechanistically, LL-37-induced activation of membrane receptors and subsequent signaling pathways lead to alteration of cellular functions. Different membrane receptors on various cancer cells appear to be responsible for the tissue-specific effects of LL-37. Meanwhile, the findings that vitamin D-dependent induction of cathelicidin in human macrophages activates the anti-cancer activity of tumor-associated macrophages (TAMs) and enhances antibody-dependent cellular cytotoxicity (ADCC) support critical roles of vitamin D-dependent induction of cathelicidin in cancer progression. This review describes...Continue Reading

Citations

Feb 23, 2019·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Sibylle Angele, Claudia Calero
Aug 13, 2020·Critical Reviews in Biotechnology·Margit MahlapuuJonas Ekblom
Jun 23, 2020·Journal of Peptide Science : an Official Publication of the European Peptide Society·Athanasios TzitzilisEugenia Panou-Pomonis
Sep 29, 2020·Frontiers in Microbiology·Morgan A AlfordRobert E W Hancock
Jul 25, 2019·International Journal of Molecular Sciences·Stacey A Krepel, Ji Ming Wang
Oct 20, 2020·Frontiers in Immunology·Derry K Mercer, Deborah A O'Neil
Nov 17, 2020·Frontiers in Microbiology·Lucas AssoniMichelle Darrieux
Mar 7, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sonia ChauhanSimran Preet
Apr 9, 2020·Biochemical and Biophysical Research Communications·Ferenc Zsila, Tamás Beke-Somfai
Dec 1, 2020·Biochemical Pharmacology·Francesco Di VirgilioAlba Clara Sarti
Oct 23, 2020·Current Topics in Medicinal Chemistry·Samuel J S Rubin, Nir Qvit
Aug 28, 2021·Biomolecules·Olalekan Olanrewaju BakareMarshall Keyster
Oct 29, 2021·Frontiers in Molecular Biosciences·Ferenc ZsilaTamás Beke-Somfai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody-Dependent Cell Cytotoxicity

Antibody-dependent cellular toxicity refers to the lysis of a target cell by a non-sensitized effector cell of the immune system as a result of antibodies binding to the target cell membrane and engaging the Fc receptors on the immune effector cells. Find the latest research on antibody-dependent cellular toxicity here.

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Adrenocortical Carcinoma

Adrenocortical carcinoma (ACC) is a rare malignancy of the adrenal cortex, associated with a generally dismal prognosis owing to its aggressive behavior. Here are the latest discoveries pertaining to this disease.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Archivum Immunologiae Et Therapiae Experimentalis
Ewelina PiktelRobert Bucki
Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Dalia H El-Rouby
© 2022 Meta ULC. All rights reserved