Roles for ER:endosome membrane contact sites in ligand-stimulated intraluminal vesicle formation

Biochemical Society Transactions
Louise H WongC E Futter

Abstract

Multivesicular endosomes/bodies (MVBs) sort membrane proteins between recycling and degradative pathways. Segregation of membrane proteins onto intraluminal vesicles (ILVs) of MVBs removes them from the recycling pathway and facilitates their degradation following fusion of MVBs with lysosomes. Sorting of many cargos onto ILVs depends on the ESCRT (Endosomal Sorting Complex Required for Transport) machinery, although ESCRT-independent mechanisms also exist. In mammalian cells, efficient sorting of ligand-stimulated epidermal growth factor receptors onto ILVs also depends on the tyrosine phosphatase, PTP1B, an ER-localised enzyme that interacts with endosomal targets at membrane contacts between MVBs and the ER. This review focuses on the potential roles played by ER:MVB membrane contact sites in regulating ESCRT-dependent ILV formation.

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Citations

Oct 31, 2019·Cellular and Molecular Life Sciences : CMLS·Elsa Meneses-SalasCarles Rentero
Dec 20, 2019·Traffic·Jean Gruenberg
Sep 21, 2020·The British Journal of Ophthalmology·Alan Bird
Apr 20, 2021·Biochimica Et Biophysica Acta. Molecular Cell Research·Anthony J MorganAntony Galione
Jun 30, 2019·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Thomas Di MattiaFabien Alpy

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