Oct 26, 1999

Roles for glycosylation of cell surface receptors involved in cellular immune recognition

Journal of Molecular Biology
P M RuddIan A Wilson

Abstract

The majority of cell surface receptors involved in antigen recognition by T cells and in the orchestration of the subsequent cell signalling events are glycoproteins. The length of a typical N-linked sugar is comparable with that of an immunoglobulin domain (30 A). Thus, by virtue of their size alone, oligosaccharides may be expected to play a significant role in the functions and properties of the cell surface proteins to which they are attached. A databank of oligosaccharide structures has been constructed from NMR and crystallographic data to aid in the interpretation of crystal structures of glycoproteins. As unambiguous electron density can usually only be assigned to the glycan cores, the remainder of the sugar is then modelled into the crystal lattice by superimposing the appropriate oligosaccharide from the database. This approach provides insights into the roles that glycosylation might play in cell surface receptors, by providing models that delineate potential close packing interactions on the cell surface. It has been proposed that the specific recognition of antigen by T cells results in the formation of an immunological synapse between the T cell and the antigen-presenting cell. The cell adhesion glycoproteins, su...Continue Reading

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Mentioned in this Paper

Human Class I Antigens
Muscle Rigidity
T-Lymphocyte
Ltbr
Crc
Calr
Leukocyte Differentiation Antigens, Human
Immunoglobulin Activity
Antigen-Presenting Cells
Golgi Apparatus

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