Roles for Histone Acetylation in Regulation of Telomere Elongation and Two-cell State in Mouse ES Cells

Journal of Cellular Physiology
Jiameng DanLin Liu

Abstract

Mammalian telomeres and subtelomeres are marked by heterochromatic epigenetic modifications, including repressive DNA methylation and histone methylation (e.g., H3K9me3 and H4K20me3). Loss of these epigenetic marks results in increased rates of telomere recombination and elongation. Other than these repressive epigenetic marks, telomeric and subtelomeric H3 and H4 are underacetylated. Yet, whether histone acetylation also regulates telomere length has not been directly addressed. We thought to test the effects of histone acetylation levels on telomere length using histone deacetylase (HDAC) inhibitor (sodium butyrate, NaB) that mediates histone hyperacetylation and histone acetyltransferase (HAT) inhibitor (C646) that mediates histone hypoacetylation. We show that histone hyperacetylation dramatically elongates telomeres in wild-type ES cells, and only slightly elongates telomeres in Terc(-/-) ES cells, suggesting that Terc is involved in histone acetylation-induced telomere elongation. In contrast, histone hypoacetylation shortens telomeres in both wild-type and Terc(-/-) ES cells. Additionally, histone hyperacetylation activates 2-cell (2C) specific genes including Zscan4, which is involved in telomere recombination and elong...Continue Reading

References

Jul 15, 1999·Cytometry·S S PoonP M Lansdorp
Jun 16, 2001·Science·J A BaurW E Wright
Sep 27, 2001·Cell·E H Blackburn
Feb 19, 2002·Oncogene·Simon W-L Chan, Elizabeth H Blackburn
May 24, 2005·Cell Cycle·Susana Gonzalo, María A Blasco
Oct 26, 2005·Human Molecular Genetics·Alessandra Muntoni, Roger R Reddel
Mar 28, 2006·Nature Cell Biology·Susana GonzaloMaría A Blasco
Jan 2, 2007·Cloning and Stem Cells·Toru SuzukiHiroshi Imai
Mar 17, 2007·Nature Reviews. Genetics·María A Blasco
Jun 8, 2007·Developmental Biology·Geppino FalcoMinoru S H Ko
Jul 3, 2007·Nature·Tarjei S MikkelsenBradley E Bernstein
Sep 12, 2007·The Journal of Cell Biology·Roberta BenettiMaría A Blasco
Nov 6, 2007·Nature Cell Biology·Lin LiuDavid L Keefe
Aug 6, 2008·Annual Review of Genetics·Wilhelm Palm, Titia de Lange
Oct 14, 2008·Nature Biotechnology·Danwei HuangfuDouglas A Melton
Mar 26, 2010·Nature·Michal ZalzmanMinoru S H Ko
Jun 18, 2010·The Journal of Biological Chemistry·Gaoyang LiangYi Zhang
Mar 2, 2011·Genes & Development·Todd S MacfarlanSamuel L Pfaff
Jun 23, 2012·Nature·Todd S MacfarlanSamuel L Pfaff
Jul 6, 2012·Nature·Azim Surani, Julia Tischler
Feb 1, 2014·Protein & Cell·Yu YinLin Liu
May 29, 2014·Development·Maria-Elena Torres-Padilla, Ian Chambers

❮ Previous
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Citations

Jul 5, 2015·Current Allergy and Asthma Reports·Saman SabounchiKari Nadeau
Jun 22, 2016·Current Opinion in Chemical Biology·Georgina Et Blake, Erica D Watson
Sep 30, 2016·Cell Reports·Mélanie A Eckersley-MaslinWolf Reik
May 15, 2018·International Journal of Molecular Sciences·Carlos Manuel Zapata-Martín Del CampoVerónica Guarner-Lans
Jan 30, 2019·Genes & Development·Mélanie Eckersley-MaslinWolf Reik
Aug 2, 2019·EMBO Molecular Medicine·Rebecca L McIntyreGeorges E Janssens
Nov 24, 2018·Molecular Cancer·Benedetta DonatiAlessia Ciarrocchi
Jul 16, 2019·Nucleic Acids Research·Weiyu ZhangXinyi Lu
May 20, 2020·EMBO Reports·Annaelena TroianoGeppino Falco
Jul 28, 2019·Protein & Cell·Feng LiZhou Songyang
Aug 13, 2021·Nature Communications·Teresa OlbrichSergio Ruiz

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