Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer

Genomics, Proteomics & Bioinformatics
Yiwen Fang, Melissa J Fullwood

Abstract

Long non-coding RNAs (lncRNAs) play important roles in cancer. They are involved in chromatin remodeling, as well as transcriptional and post-transcriptional regulation, through a variety of chromatin-based mechanisms and via cross-talk with other RNA species. lncRNAs can function as decoys, scaffolds, and enhancer RNAs. This review summarizes the characteristics of lncRNAs, including their roles, functions, and working mechanisms, describes methods for identifying and annotating lncRNAs, and discusses future opportunities for lncRNA-based therapies using antisense oligonucleotides.

References

Feb 22, 2001·Chemistry & Biology·D A Braasch, D R Corey
Feb 16, 2002·Science·Job DekkerNancy Kleckner
Jun 24, 2004·Nature Reviews. Genetics·Lin He, Gregory J Hannon
Sep 10, 2004·Nucleic Acids Research·Jianjun ChenJanet D Rowley
Mar 26, 2005·Science·Jill ChengThomas R Gingeras
Sep 6, 2005·Science·P CarninciUNKNOWN RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Sep 6, 2005·Science·S KatayamaUNKNOWN FANTOM Consortium
May 1, 2007·Nature Medicine·Alessandra CarèGianluigi Condorelli
May 18, 2007·Annual Review of Cell and Developmental Biology·Natascha Bushati, Stephen M Cohen
Aug 19, 2007·Nature Methods·Margaret S EbertPhillip A Sharp
Sep 6, 2007·PloS One·Imad J MatoukEithan Galun
Apr 24, 2008·Nature Reviews. Molecular Cell Biology·Todd RileyArnold Levine
May 27, 2008·Genome Research·Vijay K TiwariStephen B Baylin
Nov 19, 2008·Nature Reviews. Genetics·Zhong WangMichael Snyder
Dec 6, 2008·Science·Pascal PrekerTorben Heick Jensen
Feb 4, 2009·Nature Reviews. Genetics·Tim R MercerJohn S Mattick
Mar 3, 2009·Molecular Cell·Salah MahmoudiMarianne Farnebo
May 15, 2009·PloS One·Silvia M SirchiaMonica Miozzo
May 16, 2009·European Journal of Gastroenterology & Hepatology·Imad J MatoukMutaz Akkawi
Jul 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ahmad M KhalilJohn L Rinn
Aug 15, 2009·EMBO Reports·Julia Berretta, Antonin Morillon
Oct 5, 2010·Current Opinion in Pharmacology·A Keith Dunker, Vladimir N Uversky
Nov 9, 2010·Nature Methods·Jason G UnderwoodDavid Haussler
Dec 8, 2010·Proceedings of the National Academy of Sciences of the United States of America·Kavitha SarmaJeannie T Lee
Dec 22, 2010·Molecular Cell·Jing ZhaoJeannie T Lee
Jan 8, 2011·World Journal of Surgery·Sarah M WeakleyChangyi Chen

❮ Previous
Next ❯

Citations

May 3, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yu ZhangChunshui Lin
Apr 5, 2016·International Journal of Molecular Sciences·Fang LiXianqun Fan
Jul 30, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xiaozhu ZhengPeipei Guo
Oct 19, 2016·Molecular BioSystems·Yifan LianKeming Wang
Sep 22, 2016·Expert Review of Molecular Diagnostics·Jörg EllingerDimo Dietrich
Oct 26, 2016·Nitric Oxide : Biology and Chemistry·Da-Bin KuangXiao-Ping Chen
Feb 24, 2017·International Journal of Molecular Sciences·Li ZhangKa Fai To
Mar 9, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gaia PalminiMaria Luisa Brandi
Jul 14, 2017·International Journal of Molecular Sciences·Cecilia Pop-BicaIoana Berindan-Neagoe
Dec 6, 2017·International Journal of Molecular Sciences·Alexandra Iulia IrimieIoana Berindan-Neagoe
Feb 7, 2018·International Journal of Molecular Sciences·Stefania TrinoLuciana De Luca
Mar 2, 2018·Genes·Alexandra Iulia IrimieIoana Berindan-Neagoe
Mar 27, 2018·CNS Neuroscience & Therapeutics·Wen WangJi-Zong Zhao
Feb 3, 2018·Journal of Cellular and Molecular Medicine·Zhongju ShiShiqing Feng
Oct 20, 2017·Genome Biology and Evolution·Matheus Sanitá Lima, David Roy Smith
Oct 25, 2017·Cancer Biomarkers : Section a of Disease Markers·Xiaoqin ZhuJunming Guo
Sep 28, 2018·Cellular Oncology (Dordrecht)·Pouria SamadiMassoud Saidijam
Feb 13, 2018·Nature Communications·Tetsutaro HayashiItoshi Nikaido
Jan 27, 2019·Non-coding RNA·Romana ButovaRoman Hajek
Jan 3, 2019·Genomics & Informatics·Niloofar AvazpourAli Mohammad Foroughmand
Mar 5, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Chiara BraconiJesper B Andersen
Apr 18, 2019·Cancer Biology & Therapy·Jiping WangPeter H King
Apr 28, 2019·Bioscience Reports·Zheng WangDaorong Wang
May 23, 2019·Endocrine-related Cancer·Meng JiChenghao Shao
Apr 16, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Runping LiuHuiping Zhou
Jun 5, 2019·Journal of Cellular Biochemistry·Gang LiRong Pu
Jul 23, 2019·Genetic Testing and Molecular Biomarkers·Halima SiddiqueHadeil Alsufiani
Jul 28, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Zhen ZengYinying Lu
Aug 6, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Xinxin ChenXiao Wang
Jul 3, 2019·Proceedings of the National Academy of Sciences of the United States of America·Chenfeng WangYide Mei
Jun 7, 2019·Journal of Cellular Physiology·Bahman YousefiMajid Eslami
Sep 13, 2019·Wiley Interdisciplinary Reviews. RNA·Prakash KharelSoumitra Basu
Jul 12, 2017·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Kinan Drak Alsibai, Didier Meseure
Oct 10, 2019·Cancer Biotherapy & Radiopharmaceuticals·Hui GaoJing Qi
Sep 13, 2019·Cellular & Molecular Immunology·Akhilesh Kumar, Himanshu Kumar
Jan 4, 2018·Blood Advances·Chi-Yuan YaoHwei-Fang Tien
Dec 10, 2019·The Journal of Experimental Medicine·Yirong WangYifeng Zhou

❮ Previous
Next ❯

Methods Mentioned

BETA
RNA-seq
immunoprecipitation
PCR
antisense oligonucleotide
enzyme replacement therapy

Software Mentioned

RaNa
lncRNome
FANTOM
LNCipedia
ENCODE
Hi
TCGA
PARS
HOTAIR

Related Concepts

Related Feeds

CRISPR Ribonucleases Deactivation

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on mechanisms that underlie deactivation of CRISPR ribonucleases. Here is the latest research.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.

Antisense Oligonucleotides: ND

This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.

CRISPR (general)

Clustered regularly interspaced short palindromic repeats (CRISPR) are DNA sequences in the genome that are recognized and cleaved by CRISPR-associated proteins (Cas). CRISPR-Cas system enables the editing of genes to create or correct mutations. Discover the latest research on CRISPR here.

CRISPR for Genome Editing

Genome editing technologies enable the editing of genes to create or correct mutations. Clustered regularly interspaced short palindromic repeats (CRISPR) are DNA sequences in the genome that are recognized and cleaved by CRISPR-associated proteins (Cas). Here is the latest research on the use of CRISPR-Cas system in gene editing.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cancer Epigenetics Chromatin Complexes (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on chromatin complexes and their role in cancer epigenetics.

Cancer Epigenetics and Chromatin (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on chromatin and its role in cancer epigenetics please follow this feed to learn more.

CRISPR in Cancer

CRISPR-Cas system enables the editing of genes to create or correct mutations. Given that genome instability and mutation is one of the hallmarks of cancer, the CRISPR-Cas system is being explored to genetically alter and eliminate cancer cells. Here is the latest research.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Related Papers

Cellular & Molecular Immunology
Yuan Zhang, Xuetao Cao
Biochemical and Biophysical Research Communications
Yu-Chan Zhang, Yueqin Chen
World Journal of Gastroenterology : WJG
Wei-Jun CaoZhen-Yu Zhang
© 2022 Meta ULC. All rights reserved