Roles of amino acid derivatives in the regulation of obesity.

Food & Function
Jie ZhengTiejun Li

Abstract

Obesity is an issue of great concern to people all over the world. It is accompanied by serious complications, leading to reduced quality of life and higher morbidity and mortality. Over the past few years, there has been an explosion in knowledge about the roles of potential therapeutic agents in obesity management. Among them, amino acid (AA) derivatives, such as taurine, glutathione (GSH), betaine, α-ketoglutarate (AKG), β-aminoisobutyric acid (BAIBA), and β-hydroxy-β-methylbutyrate (HMB), have recently gained popularity due to their beneficial effects on the promotion of weight loss and improvement in the lipid profile. The mechanisms of action of these derivatives mainly include inhibiting adipogenesis, increasing lipolysis, promoting brown/beige adipose tissue (BAT) development, and improving glucose metabolism. Therefore, this review summarizes these AA derivatives and the possible mechanisms responsible for their anti-obesity effects. Based on the current findings, these AA derivatives could be potential therapeutic agents for obesity and its related metabolic diseases.

References

Jan 1, 1992·Physiological Reviews·R J Huxtable
Apr 1, 1991·Metabolism: Clinical and Experimental·M JeevanandamW R Schiller
Jan 1, 1983·Annual Review of Biochemistry·A Meister, M E Anderson
Mar 9, 1995·The New England Journal of Medicine·R L LeibelJ Hirsch
Oct 14, 1994·Clinica Chimica Acta; International Journal of Clinical Chemistry·M LeverS T Chambers
Nov 5, 1999·JAMA : the Journal of the American Medical Association·A MustW H Dietz
Nov 24, 1999·Free Radical Biology & Medicine·O W Griffith
Mar 8, 2002·Journal of Animal Science·I Fernández-FígaresT J Caperna
Nov 19, 2002·Amino Acids·J D Militante, J B Lombardini
May 6, 2003·The Journal of Nutrition·Steven H ZeiselJoanne M Holden
Sep 1, 1953·Archives of Biochemistry and Biophysics·H J STRECKER
Dec 16, 2004·The Journal of Clinical Investigation·Shigetada FurukawaIichiro Shimomura
Mar 12, 2005·Annual Review of Public Health·David L Katz
Apr 22, 2006·Endocrinology·Nobuyo Tsuboyama-KasaokaOsamu Ezaki
May 17, 2006·The Journal of Nutrition·Martha H StipanukRelicardo M Coloso
Jul 4, 2006·European Journal of Pharmacology·Yeda S DinizEthel L B Novelli
Dec 15, 2006·Nature·Steven E KahnKristina M Utzschneider
Oct 22, 2008·Scandinavian Journal of Clinical and Laboratory Investigation·Radoslaw P RadzkiStefan G Pierzynowski
Apr 16, 2009·American Journal of Physiology. Endocrinology and Metabolism·Hironori KobayashiIichiro Shimomura
Feb 4, 2010·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·D Withrow, D A Alter
May 7, 2010·Journal of Inherited Metabolic Disease·Per Magne Ueland
Sep 17, 2010·American Journal of Physiology. Cell Physiology·Haruki HigashimoriJessica A Filosa
Jan 18, 2011·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·F Gerlinger-RomeroM T Nunes
Apr 20, 2012·Journal of the International Society of Sports Nutrition·Jacob M WilsonJeong-Su Kim
Oct 31, 2012·The British Journal of Nutrition·Margriet S Westerterp-PlantengaKlaas R Westerterp
Jun 8, 2013·Clinical Science·Angélica Ruiz-RamírezMohammed El-Hafidi
Jul 5, 2013·Cell Metabolism·Eugene P RheeRobert E Gerszten
Jul 24, 2013·Metabolism: Clinical and Experimental·Bong-Sup ParkJeong-Su Kim
Aug 24, 2013·Journal of the International Society of Sports Nutrition·Jason M CholewaVincent Paolone
Sep 4, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Ana P CappelliEverardo M Carneiro
Sep 26, 2013·European Journal of Nutrition·Flávia Troncon RosaJulio Sérgio Marchini

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear translocation

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Critical Reviews in Food Science and Nutrition
Han-Ning WangMin Du
Acta poloniae pharmaceutica
S RolskiK Jakimowska
Antibiotics & Chemotherapy
D L JONESH J BYRNE
© 2021 Meta ULC. All rights reserved