PMID: 6990015Apr 1, 1980Paper

Roles of bacteriophage T4 gene 5 and gene s products in cell lysis

Journal of Virology
S H Kao, W H McClain

Abstract

Previous studies indicated that (i) T4 gene s product (gps) protects infected cells from superinfection lysis from without, (ii) the absence of gps in infected cells also leads to lysis from within even when T4 e lysozyme is absent, (iii) T4 gene 5 product (gp5), a polypeptide of the virion baseplate, may be responsible for inducing lysis from without, and (iv) altered gp5 of the T4 mutant 5ts1 can replace e lysozyme to cause lysis from within. Results of this study showed that (i) wild-type gp5 in infected cells lacking e lysozyme was responsible for lysis from within in the absence of gps, and (ii) gps did not protect infected cells from superinfection lysis from without by 5ts1 phage. We prpose that gps normally prevents functional expression of wild-type gp5 activity from either side of the cell wall, whereas the 5ts1 form of gp5 is insensitive to the gps barrier and induces lysis from either side of the cell wall.

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Apr 1, 1980·Journal of Virology·S H Kao, W H McClain
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Citations

Mar 11, 2003·Microbiology and Molecular Biology Reviews : MMBR·Eric S MillerWolfgang Rüger
Jul 17, 2012·Journal of Bacteriology·Nichole CumbyKaren L Maxwell
Sep 3, 2020·Acta Crystallographica. Section D, Structural Biology·Ke ShiHideki Aihara
May 17, 2017·Biophysics Reviews·Fumio ArisakaMichael G Rossmann
Jun 28, 2005·Antimicrobial Agents and Chemotherapy·Marian Takác, Udo Bläsi
Aug 19, 2015·Proceedings of the National Academy of Sciences of the United States of America·Bo HuJun Liu
Nov 21, 2020·Communications Biology·Ke ShiHideki Aihara
Sep 15, 1994·FEMS Microbiology Letters·Y S TarahovskyA A Khusainov
May 20, 2015·Structure·Thomas KloseMichael G Rossmann
Jul 27, 1999·Virology·T KaiT Yonesaki
Apr 1, 1980·Journal of Virology·S H Kao, W H McClain
Nov 13, 1981·Biochimica Et Biophysica Acta·B Szewczyk, R Skórko
Sep 1, 1992·Microbiological Reviews·R Young
Apr 1, 1994·Trends in Microbiology·M J Lu, U Henning
Oct 21, 1990·Journal of Theoretical Biology·S T Abedon

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