Roles of c-Met and RON kinases in tumor progression and their potential as therapeutic targets

Oncotarget
Katherine ChangJames W Freeman

Abstract

c-Met and receptor originated from nantes (RON) are structurally related transmembrane phosphotyrosine kinase receptors. c-Met and RON show increased expression or activity in a variety of tumors leading to tumor progression and may play a role in acquired resistance to therapy. Although often co-expressed, the distinct functional roles of c-Met and RON are not fully understood. c-Met and RON form both activated homodimers and heterodimers with themselves and other families of phosphotyrosine kinase receptors. Inhibitors for c-Met and RON including small molecular weigh kinase inhibitors and neutralizing antibodies are in pre-clinical investigation and clinical trials. Several of the tyrosine kinase inhibitors have activity against both c-Met and RON kinases whereas the antibodies generally are target specific. As with many targeted agents used to treat solid tumors, it is likely that c-Met/RON inhibitors will have greater benefit when used in combination with chemotherapy or other targeted agents. A careful analysis of c-Met/RON expression or activity and a better elucidation of how they influence cell signaling will be useful in predicting which tumors respond best to these inhibitors as well as determining which agents can b...Continue Reading

References

Aug 16, 1984·Biochemical and Biophysical Research Communications·T NakamuraA Ichihara
Dec 1, 1994·Protein Science : a Publication of the Protein Society·L E DonateT L Blundell
Dec 1, 1996·Molecular and Cellular Biology·M M SantoroP M Comoglio
Jun 29, 2000·Oncogene·A FollenziP M Comoglio
Dec 5, 2002·Genes & Development·Véronique Orian-RousseauHelmut Ponta
Aug 14, 2003·Experimental Cell Research·Piera MaggioraMaria Flavia Di Renzo
Dec 8, 2004·Current Opinion in Structural Biology·Ermanno GherardiE Yvonne Jones
Apr 14, 2005·Annals of Surgical Oncology·E Ramsay CampLee M Ellis
Jul 4, 2007·Journal of Cellular Physiology·Silvia Benvenuti, Paolo M Comoglio
Dec 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·James BeanWilliam Pao
Jan 1, 2008·The Journal of Biological Chemistry·Amalraj ThangasamySudhakar Ammanamanchi
Aug 19, 2008·Genes, Chromosomes & Cancer·Patrick C MaRavi Salgia
Feb 10, 2009·Anti-cancer Agents in Medicinal Chemistry·Isabelle Dussault, Steven F Bellon
Mar 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Federico CappuzzoMarileila Varella-Garcia
Mar 26, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Joseph Paul EderPatricia M LoRusso
Jul 2, 2009·Proceedings of the National Academy of Sciences of the United States of America·Carrie R GraveelGeorge F Vande Woude
Dec 25, 2009·Trends in Molecular Medicine·Xiangdong LiuPeggy A Scherle
Jun 17, 2010·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Toshikazu Nakamura, Shinya Mizuno
Jul 31, 2010·Microbes and Infection·Laurent DortetPascale Cossart
Aug 7, 2010·Neoplasia : an International Journal for Oncology Research·Rebecca J McClaineSusan E Waltz
Jan 8, 2011·Cancer Research·Silvia BenvenutiPaolo M Comoglio
Mar 23, 2011·Oncogene·A M DulakJ M Siegfried
May 14, 2011·Carcinogenesis·Dawn V JaquishAndrew M Lowy
Jun 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Yunqing LiJohn Laterra
Jul 20, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lecia V SequistJoan H Schiller

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Citations

Nov 7, 2015·Oncotarget·Alana L GrayJames A Cardelli
Mar 23, 2017·Molecular Cancer·Michela Lupia, Ugo Cavallaro
Jan 7, 2017·Cold Spring Harbor Symposia on Quantitative Biology·Najme Faham, Alana L Welm
Mar 14, 2019·Frontiers in Endocrinology·Anne-Marie BairdSteven G Gray
May 2, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Elmira Safaie QamsariMehdi Yousefi
Nov 5, 2016·Journal of Cancer Research and Clinical Oncology·Omid ZareiSiavoush Dastmalchi
Nov 27, 2016·Archives of Gynecology and Obstetrics·Ping XuXinmei Zhang
Dec 19, 2018·Veterinary Pathology·Lorella ManiscalcoRaffaella De Maria
Jun 8, 2021·World Journal of Gastroenterology : WJG·Shao-Long ChenHang-Ping Yao
Dec 21, 2018·Journal of Medicinal Chemistry·Vishnu C DamalankaJames W Janetka

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Methods Mentioned

BETA
flow cytometry

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