Aug 1, 2018

Roles of cardiac sympathetic neuroimaging in autonomic medicine

Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society
David S Goldstein, William P Cheshire

Abstract

Sympathetic neuroimaging is based on the injection of compounds that either radiolabel sites of the cell membrane norepinephrine transporter (NET) or that are taken up into sympathetic nerves via the NET and radiolabel intra-neuronal catecholamine storage sites. Detection of the radioactivity is by planar or tomographic radionuclide imaging. The heart stands out among body organs in terms of the intensity of radiolabeling of sympathetic nerves, and virtually all of sympathetic neuroimaging focuses on the left ventricular myocardium. The most common cardiac sympathetic neuroimaging method worldwide is 123I-metaiodobenzylguanidine (123I-MIBG) scanning. 123I-MIBG scanning is used routinely in Europe and East Asia in the diagnostic evaluation of neurogenic orthostatic hypotension (nOH), to distinguish Lewy body diseases (e.g., Parkinson disease with orthostatic hypotension (OH), pure autonomic failure) from non-Lewy body diseases (e.g., multiple system atrophy) and to distinguish dementia with Lewy bodies from Alzheimer's disease. In the USA, 123I-MIBG scanning has been approved by the Food and Drug Administration for the evaluation of pheochromocytoma and some forms of heart failure-but not for the above-mentioned differential dia...Continue Reading

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Citations

Mentioned in this Paper

Autonomic Nervous System Disorders
Aspects of Radionuclide Imaging
Nervousness
SLC6A2 protein, human
Neuroendocrine Tumors
Norepinephrine Plasma Membrane Transport Proteins
Academic Medical Centers
Medicine
Myocardium of Left Ventricle
Positron-Emission Tomography

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