Roles of collecting duct renin and (pro)renin receptor in hypertension: mini review

Therapeutic Advances in Cardiovascular Disease
Alexis A Gonzalez, Minolfa C Prieto

Abstract

In angiotensin (Ang)-II-dependent hypertension, collecting duct renin synthesis and secretion are stimulated despite suppression of juxtaglomerular (JG) renin. This effect is mediated by Ang II type 1 (AT1) receptor independent of blood pressure. Although the regulation of JG renin is known, the mechanisms by which renin is regulated in the collecting duct are not completely understood. The presence of renin activity in the collecting duct may provide a pathway for intratubular Ang II formation since angiotensinogen substrate and angiotensin converting enzyme are present in the distal nephron. The recently named new member of the renin-angiotensin system (RAS), the (pro)renin receptor [(P)RR], is able to bind renin and the inactive prorenin, thus enhancing renin activity and fully activating prorenin. We have demonstrated that renin and (P)RR are augmented in renal tissues from rats infused with Ang II and during sodium depletion, suggesting a physiological role in intrarenal RAS activation. Importantly, (P)RR activation also causes activation of intracellular pathways associated with increased cyclooxygenase 2 expression and induction of profibrotic genes. In addition, renin and (P)RR are upregulated by Ang II in collecting du...Continue Reading

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Citations

Jun 3, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Carlos M Ferrario, Adam E Mullick
Feb 20, 2018·Molecular and Cellular Biochemistry·Antônio da Silva NovaesMirian Aparecida Boim
May 2, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jie LiuHua Peng
Oct 18, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Mark C Chappell
Apr 5, 2017·Physiological Reports·Lucienne S LaraMinolfa C Prieto
Mar 16, 2018·Current Hypertension Reports·Fernando Pedro de Souza-NetoRafaela Fernandes da Silva
Dec 8, 2020·Frontiers in Physiology·Andrew C CurnowMinolfa C Prieto
Aug 3, 2021·American Journal of Physiology. Renal Physiology·Friederike KesselVladimir T Todorov

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
transgenic
immunoprecipitation

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