Roles of connexins in testis development and spermatogenesis

Seminars in Cell & Developmental Biology
Gerald M Kidder, Daniel G Cyr

Abstract

The development and differentiation of cells involved in spermatogenesis requires highly regulated and coordinated interactions between cells. Intercellular communication, particularly via connexin43 (Cx43) gap junctions, plays a critical role in the development of germ cells during fetal development and during spermatogenesis in the adult. Loss of Cx43 in the fetus results in a decreased number of germ cells, while the loss of Cx43 in the adult Sertoli cells results in complete inhibition of spermatogenesis. Connexins 26, 32, 33, 36, 45, 46 and 50 have also been localized to specific compartments of the testis in various mammals. Loss of Cx46 is associated with an increase in germ cell apoptosis and loss of the integrity of the blood-testis barrier, while loss of other connexins appears to have more subtle effects within the seminiferous tubule. Outside the seminiferous tubule, the interstitial Leydig cells express connexins 36 and 45 along with Cx43; deletion of the latter connexin did not reveal it to be crucial for steroidogenesis or for the development and differentiation of Leydig cells. In contrast, loss of Cx43 from Sertoli cells results in Leydig cell hyperplasia, suggesting important cross-talk between Sertoli and Ley...Continue Reading

References

Jun 1, 1982·The Anatomical Record·E L Sun, C J Flickinger
Apr 10, 1996·Developmental Biology·M ChangG Dahl
Oct 15, 1998·Experimental Cell Research·H Merchant-Larios, N Moreno-Mendoza
Nov 11, 1998·Developmental Biology·J Karl, B Capel
Apr 20, 1999·Biology of Reproduction·S C JunejaG M Kidder
Sep 21, 2000·Current Biology : CB·A PlumK Willecke
Aug 22, 2001·Biology of Reproduction·W A RoscoeG M Kidder
Oct 12, 2001·The Anatomical Record·E M Pérez-ArmendarizJ F Bravo Moreno
Oct 22, 2002·American Journal of Physiology. Cell Physiology·Julie DufresneDaniel G Cyr
Mar 23, 2004·Biochimica Et Biophysica Acta·Gary S GoldbergPeter R Brink
Mar 26, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Vincent M ChristoffelsMarina Campione
May 12, 2004·Journal of Cellular Physiology·X DecrouyD Segretain
Apr 28, 2005·Cell and Tissue Research·Denise R Holsberger, Paul S Cooke
Sep 13, 2005·Development·Ann M FlennikenJanet Rossant
Feb 24, 2006·The Biochemical Journal·Dale W Laird
Sep 30, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Caroline N KahiriGerald M Kidder
May 18, 2007·Progress in Biophysics and Molecular Biology·Alonso P Moreno, Alan F Lau
Jun 27, 2007·The American Journal of Pathology·Ralph BrehmMartin Bergmann
Oct 2, 2007·Annals of the New York Academy of Sciences·Santhi SridharanPaul S Cooke
Oct 12, 2007·Biology of Reproduction·Evemie DubéDaniel G Cyr
Mar 25, 2009·The Biochemical Journal·Joell L Solan, Paul D Lampe
Apr 21, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Georges PointisDominique Segretain
Jun 18, 2010·Canadian Journal of Physiology and Pharmacology·Gerald M Kidder, Barbara C Vanderhyden
Jul 27, 2010·Developmental Biology·Diane CaretteGeorges Pointis
Jun 28, 2011·Progress in Histochemistry and Cytochemistry·R-Marc Pelletier
Dec 6, 2011·The Journal of Biological Chemistry·Clarence A DunnPaul D Lampe

❮ Previous
Next ❯

Citations

Jul 15, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·Pavel BabicaBrad L Upham
Nov 7, 2016·Toxicology and Applied Pharmacology·Yandi WangLingjiang Min
Jul 31, 2018·Biology of Reproduction·Mary Gregory, Daniel G Cyr
Jan 23, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Petra KubincováIva Sovadinová
Apr 30, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·R-Marc PelletierMaría Leiza Vitale
Jun 28, 2020·Journal of Cellular Physiology·Louise NugentCatherine S Wright
Jun 12, 2020·The Journal of Clinical Investigation·Shaohua XiaoRobin M Shaw
Nov 12, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Fritz G Rathjen
Sep 29, 2019·Seminars in Cell & Developmental Biology·Dana Landschaft
Feb 17, 2021·Communications Biology·Diego CrespoRüdiger W Schulz
Aug 8, 2021·International Journal of Molecular Sciences·Kristina RodeRalph Brehm
Aug 10, 2021·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·Derya KarabulutBirkan Yakan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis