Roles of cytosolic Ca2+ concentration and myofilament Ca2+ sensitization in age-dependent cerebrovascular myogenic tone.

American Journal of Physiology. Heart and Circulatory Physiology
Shelton M CharlesW J Pearce

Abstract

In light of evidence that immature arteries contain a higher proportion of noncontractile smooth muscle cells than found in fully differentiated mature arteries, the present study explored the hypothesis that age-related differences in the smooth muscle phenotype contribute to age-related differences in contractility. Because Ca(2+) handling differs markedly between contractile and noncontractile smooth muscle, the present study specifically tested the hypothesis that the relative contributions of Ca(2+) influx and myofilament sensitization to myogenic tone are upregulated, whereas Ca(2+) release is downregulated, in immature [14 days postnatal (P14)] compared with mature (6 mo old) rat middle cerebral arteries (MCAs). Myofilament Ca(2+) sensitivity measured in β-escin-permeabilized arteries increased with pressure in P14 but not adult MCAs. Cyclopiazonic acid (an inhibitor of Ca(2+) release from the sarcoplasmic reticulum) increased diameter and reduced Ca(2+) in adult MCAs but increased diameter with no apparent change in Ca(2+) in P14 MCAs. La(3+) (Ca(2+) influx inhibitor) increased diameter and decreased Ca(2+) in adult MCAs, but in P14 MCAs, La(3+) increased diameter with no apparent change in Ca(2+). After treatment with ...Continue Reading

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Citations

Sep 21, 2012·American Journal of Physiology. Cell Physiology·Margaret C HubbellWilliam J Pearce
Jun 10, 2011·American Journal of Physiology. Cell Physiology·Stacy M ButlerWilliam J Pearce
Dec 7, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Charles W LefflerAlexander L Fedinec
Jan 18, 2013·American Journal of Physiology. Cell Physiology·Olayemi O AdeoyeWilliam J Pearce
Aug 2, 2013·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Y P ZhangY H Si
May 28, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Richard B ThorpeWilliam J Pearce
Jan 31, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lara M DurrantWilliam J Pearce
Jul 20, 2014·Journal of Applied Physiology·Olayemi O AdeoyeWilliam J Pearce
Oct 7, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·William J PearceJiping Tang
Oct 3, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·P Naomi FrancoWilliam J Pearce
Jul 29, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dane W SorensenWilliam J Pearce

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