Roles of cytotoxic lymphocytes and MIC/LILR families in pathophysiology of Takayasu arteritis

Inflammation and Regeneration
Hajime Yoshifuji, Chikashi Terao

Abstract

Takayasu arteritis (TAK) affects the aorta and its primary branches, mainly in young women. In its advanced stages, it can cause severe complications, such as cerebral infarction, impaired vision, and valvular heart diseases. In the aortic tissue of TAK, there is increased infiltration of cytotoxic lymphocytes, such as natural killer (NK) cells and CD8+T cells, and enhanced expression of accessory molecules, such as major histocompatibility complex (MHC) and MHC class I chain-related gene (MIC) family. Genome-wide association studies on TAK have identified susceptibility genes, such as IL-12p40, MICA, MICB, leukocyte immunoglobulin-like receptor A3 (LILRA3), and LILRB3. Other studies have also shown their involvement in the pathophysiology of TAK. In addition, we reported the importance of NK cells by enhancer enrichment analysis. These results suggest that the gene polymorphisms that potentially upregulate the expression of cytokines and accessory molecules, which contribute to the activation of cytotoxic lymphocytes, are associated with the development of TAK. Based on these results, new molecular targeted therapies look promising.

References

Oct 1, 1978·Tissue Antigens·I IsohisaT Sasazuki
Jul 9, 2013·American Journal of Human Genetics·Güher Saruhan-DireskeneliAmr H Sawalha
Oct 24, 2015·Journal of Autoimmunity·Amr H Sawalha, Mikhail G Dozmorov
May 6, 2016·Frontiers in Immunology·Marc ClementKarim Sacre
Dec 1, 2018·Proceedings of the National Academy of Sciences of the United States of America·Chikashi TeraoFumihiko Matsuda
Jan 21, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Mitsuaki IsobeUNKNOWN JCS Joint Working Group

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Citations

Feb 20, 2021·Rheumatology Advances in Practice·Sebastian-Jonas SaurJörg Henes
May 1, 2021·Antibody Therapeutics·Mi DengCheng Cheng Zhang
Jun 18, 2021·International Journal of Rheumatic Diseases·Masahiro KondoMayuko Moriyama
Sep 25, 2021·Inflammation and Regeneration·Yoshiya Tanaka

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