Roles of distinct glutamate receptors in induction of anti-Hebbian long-term potentiation

The Journal of Physiology
Dimitri M Kullmann, Karri P Lamsa

Abstract

Many glutamatergic synapses on interneurons involved in feedback inhibition in the CA1 region of the hippocampus exhibit an unusual form of long-term potentiation (LTP) that is induced only if presynaptic glutamate release occurs when the postsynaptic membrane potential is relatively hyperpolarized. We have named this phenomenon 'anti-Hebbian' LTP because it is prevented by postsynaptic depolarization during afferent activity, and hence its induction requirements are opposite to those of Hebbian NMDA receptor-dependent LTP. This symposium report addresses the roles of distinct glutamate receptors in the induction of anti-Hebbian LTP. Inwardly rectifying Ca(2+)-permeable AMPA receptors mediate fast glutamatergic signalling at synapses that exhibit this form of LTP, and they are highly likely to mediate the instructive signal that triggers the cascade leading to synapse strengthening. NMDA receptors, on the other hand, play no role, nor do they contribute substantially to synaptic transmission at synapses that exhibit anti-Hebbian LTP. Both kainate and group I metabotropic glutamate receptors are abundant in at least some interneurons in the feedback inhibitory circuit. Delineating the roles of kainate receptors has been hampered...Continue Reading

References

May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S M Dudek, M F Bear
Mar 1, 1986·Experimental Neurology·S Pockett, O C Lippold
Jul 15, 1995·The Journal of Physiology·S K KambojS G Cull-Candy
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·S D Donevan, M A Rogawski
Jul 10, 1997·Nature·M Vignes, G L Collingridge
Nov 5, 1997·Trends in Neurosciences·D E Pellegrini-GiampietroR S Zukin
Apr 10, 1999·Nature Neuroscience·M FrerkingR A Nicoll
Jun 22, 1999·The Journal of Physiology·O CaillardJ L Gaiarsa
Feb 24, 2001·Cellular and Molecular Life Sciences : CMLS·D Bleakman
Jun 28, 2001·Physiological Reviews·J LermaJ C López-García
Jul 12, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y PerezJ C Lacaille
Dec 16, 2003·The Journal of Physiology·Valérie LapointeJean-Claude Lacaille
Nov 1, 1949·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·C O HEBB, H KONZETT
Jan 28, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lisa TopolnikJean-Claude Lacaille
Aug 21, 2007·Nature Reviews. Neuroscience·Dimitri M Kullmann, Karri P Lamsa
Sep 7, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Miri GoldinRosa Cossart
Sep 18, 2007·Nature Neuroscience·David SotoStuart G Cull-Candy

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Citations

Jan 9, 2010·Annual Review of Pharmacology and Toxicology·Colleen M Niswender, P Jeffrey Conn
Sep 18, 2009·Journal of Neurophysiology·John G PartridgeStefano Vicini
Jan 30, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Iris OrenKarri P Lamsa
Nov 6, 2013·Journal of Molecular Neuroscience : MN·Daniel Ortuño-SahagúnC Beas Zárate
Dec 22, 2015·Molecular and Cellular Neurosciences·Tomohiko MaruoMasahiro Mori
Feb 15, 2011·Pharmacology, Biochemistry, and Behavior·Greg C Carlson
Jan 5, 2011·Neuropharmacology·Fernanda Laezza, Raymond Dingledine
Jan 20, 2009·IEEE Transactions on Bio-medical Engineering·Zachary V FreudenburgPhilip S Ulinski
Feb 19, 2013·Neuroscience Letters·Angela N ViaeneS Murray Sherman
Feb 12, 2013·Neuron·Corentin Le Magueresse, Hannah Monyer
Jun 30, 2012·Neuropharmacology·Sreedeep Mukherjee, Denise Manahan-Vaughan
May 7, 2016·Nature Reviews. Neuroscience·Marina E Wolf
Mar 16, 2017·The Journal of Physiology·Joern R Steinert
Mar 6, 2013·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·S Murray Sherman
Jan 6, 2021·Progress in Neurobiology·Karim A Alkadhi
Jun 6, 2021·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Li-Da SuYing Shen

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