Roles of dopamine receptors in mediating acute modulation of immunological responses in Macrobrachium rosenbergii

Fish & Shellfish Immunology
Zhong-Wen ChangChin-Chyuan Chang

Abstract

Dopamine (DA) was found to influence the immunological responses and resistance to pathogen infection in invertebrates. To clarify the possible modulation of DA through dopamine receptors (DAR) against acute environmental stress, the levels of DA, glucose and lactate in the haemolymph of Macrobrachium rosenbergii under hypo- and hyperthermal stresses were measured. The changes in immune parameters such as total haemocyte count (THC), differential haemocyte count (DHC), phenoloxidase (PO) activity, respiratory bursts (RBs), superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities and phagocytic activity (PA) were evaluated in prawns which received DAR antagonists (SCH23390, SCH, D1 antagonist; domperidone, DOM, D2 antagonist; chlorpromazine, CH, D1+2 antagonist) followed by hypo- (15 °C) and hyperthermal (34 °C) stresses. In addition, pharmacological analysis of the effect DA modulation was studied in haemocytes incubated with DA and DAR antagonists. The results revealed a significant increase in haemolymph DA accompanied with upregulated levels of glucose and lactate in prawns exposed to both hypo- and hyperthermal stresses in 2 h. In addition, a significant decrease in RBs per haemocyte was noted in prawns which ...Continue Reading

References

Jan 11, 1979·Nature·J W Kebabian, D B Calne
Feb 11, 1992·Trends in Pharmacological Sciences·D R Sibley, F J Monsma
Jun 1, 1990·Trends in Pharmacological Sciences·P H AndersenM G Caron
May 1, 1993·Developmental and Comparative Immunology·K L Bell, V J Smith
Jan 1, 1993·Annual Review of Pharmacology and Toxicology·O CivelliD K Grandy
Mar 1, 1996·Progress in Neurobiology·E Ottaviani, C Franceschi
Apr 2, 1998·Current Opinion in Immunology·K Söderhäll, L Cerenius
Feb 2, 2000·Neuroscience and Biobehavioral Reviews·D ValloneE Borrelli
Nov 1, 2001·Developmental and Comparative Immunology·Arnaud LacosteSerge A Poulet
Jun 1, 1989·Parasitology Today·M W Johansson, K Soderhall
Dec 27, 2005·Fish & Shellfish Immunology·Winton ChengJiann-Chu Chen
Jan 21, 2006·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·S L HsiehC M Kuo
Jan 11, 2007·Fish & Shellfish Immunology·Chin-Chyuan ChangWinton Cheng
Dec 1, 2007·WormBook : the Online Review of C. Elegans Biology·Daniel L Chase, Michael R Koelle
Nov 10, 2009·Brain, Behavior, and Immunity·Chandrani SarkarSujit Basu
Feb 10, 2011·Pharmacological Reviews·Jean-Martin Beaulieu, Raul R Gainetdinov
Mar 30, 2011·Blood·Xionghui Lin, Irene Söderhäll
Apr 6, 2011·Fish & Shellfish Immunology·R P EllisS Widdicombe

❮ Previous
Next ❯

Citations

Nov 9, 2016·Developmental and Comparative Immunology·Ratchaneegorn MapanaoWinton Cheng
Oct 5, 2019·Developmental and Comparative Immunology·Donghong NiuJiale Li
Sep 30, 2019·Developmental and Comparative Immunology·Zhong-Wen Chang, Chin-Chyuan Chang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here