Roles of electrical stimulation in promoting osteogenic differentiation of BMSCs on conductive fibers

Journal of Biomedical Materials Research. Part a
Wei JingWeihong Zhong

Abstract

The strategy of using conductive materials in regenerating bone defects is attractive, benefiting from the bioelectricity feature of natural bone tissues. Thereby, POP conductive fibers were fabricated by coating polypyrrole (PPY) onto electrospun poly(l-lactide) (PLLA) fibers, and their potentials in promoting osteogenic differentiation of bone mesenchymal stromal cells (BMSCs) were investigated. Different from the smooth-surfaced PLLA fibers, POP fibers were rough-surfaced and favorable for protein adsorption and mineralization nucleation. When electrical stimulation (ES) was applied, the surface charges on the conductive POP fibers further promoted the protein adsorption and the mineral deposition, while the non-conductive PLLA fibers displayed no such promotion. When BMSCs were cultured on these fibers, strong cell viability was detected, indicating their good biocompatibility and cell affinity. In osteogenic differentiation studies, BMSCs demonstrated the strongest ability in differentiating toward osteoblasts when they were cultured on the POP fibers under ES, followed by the case without ES. In comparison with the conductive POP fibers, the non-conductive PLLA fibers displayed significantly weaker ability in inducing the...Continue Reading

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Citations

Jun 14, 2020·Journal of Functional Biomaterials·Giuseppe ArrabitoBruno Pignataro
Sep 24, 2020·Journal of Biomaterials Science. Polymer Edition·Jianping MaoQing Cai
Oct 1, 2020·Advanced Healthcare Materials·Amy Gelmi, Carolyn E Schutt
Oct 22, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Tianyi ZhengXiaoping Yang
Jan 13, 2021·International Journal of Molecular Sciences·Oriol CaretaCarme Nogués
Oct 30, 2020·International Journal of Molecular Sciences·Lucja Dybowska-SarapukMalgorzata Jakubowska
Jun 27, 2021·Journal of Biomedical Materials Research. Part a·Yiqian HuangXiaoping Yang
Jul 24, 2021·Colloids and Surfaces. B, Biointerfaces·Xiaojun LongHongwei Ouyang

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