Roles of fasting and postprandial blood glucose in the effect of type 2 diabetes on central arterial stiffness: a 5-year prospective community-based analysis

Diabetology & Metabolic Syndrome
Shihui FuPing Ye

Abstract

Cardiovascular disease constitutes a major challenge for the health of community-dwelling population, it is essential to delay the development of atherosclerosis. However, long-term prospective studies analyzing the effect of type 2 diabetes (T2D) on central arterial stiffness are lacking, and roles of fasting and postprandial blood glucose (FBG and PBG) in this effect are controversial. Purpose of the current analysis was to investigate the effect of T2D on central arterial stiffness during the 5 years of follow-up, and explore whether both FBG and PBG were determinants of this effect in Chinese community-dwelling population. The current analysis involved 898 individuals with carotid-femoral pulse wave velocity (cfPWV) ≤12 m/s. Central arterial stiffness was assessed by standard cfPWV at baseline and follow-up. Incidence of cfPWV >12 m/s was 21.3% (102 participants). Participants without T2D had an increase of cfPWV with a median of 0.6 m/s, whereas participants with T2D had an increase of cfPWV with a median of 1.2 m/s (p = 0.007). T2D had an independent effect on increased cfPWV in multivariate Logistic regression models (p < 0.05 for all). Elevated levels of both FBG and PBG determined the independent effect on increased cf...Continue Reading

References

Oct 15, 1994·American Journal of Epidemiology·D K ArnettW A Riley
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Dec 18, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·S MeaumeM E Safar
May 29, 2002·Diabetes Care·Kathryn C B TanKaren S L Lam
Apr 5, 2003·Stroke; a Journal of Cerebral Circulation·Stéphane LaurentPierre Boutouyrie
Jul 25, 2003·American Journal of Hypertension·Masanori MunakataKaoru Yoshinaga
Apr 13, 2004·Journal of Hypertension·Andrew L McLeodDavid E Newby
May 19, 2004·Hypertension·Lorenita De AngelisPhilip J Chowienczyk
Feb 8, 2006·Circulation·Francesco U S Mattace-RasoJacqueline C M Witteman
Sep 27, 2006·European Heart Journal·Stephane LaurentUNKNOWN European Network for Non-invasive Investigation of Large Arteries
Jun 22, 2007·Clinical and Experimental Pharmacology & Physiology·Sophia Zoungas, Roland P Asmar
Jun 22, 2007·Clinical and Experimental Pharmacology & Physiology·James D Cameron, J Kennedy Cruickshank
Mar 6, 2009·The Journal of Medical Investigation : JMI·Sekaran MuniandyArokiasamy Vinsent Rayappan
Jul 18, 2009·European Journal of Applied Physiology·Tracy BaynardJ A Kanaley
Mar 26, 2010·The New England Journal of Medicine·Wenying YangUNKNOWN China National Diabetes and Metabolic Disorders Study Group
Mar 27, 2010·Journal of the American College of Cardiology·Charalambos VlachopoulosChristodoulos Stefanadis
Nov 10, 2010·Lipids in Health and Disease·Rafael O AlvimAlexandre C Pereira
Oct 14, 2011·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Gregory VyssoulisChristodoulos Stefanadis
Jun 30, 2012·Lipids in Health and Disease·Paulo C J L SantosAlexandre C Pereira
Oct 16, 2012·Cardiovascular Diabetology·Katerina K NakaLampros K Michalis
Nov 14, 2012·Nutrition Research·Eunice Mah, Richard S Bruno

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