PMID: 11331407May 2, 2001Paper

Roles of fibroblast growth factor 2 during innervation of the avian inner ear

Journal of Neurochemistry
E CarniceroT Schimmang

Abstract

The importance of individual members of the fibroblast growth factor gene family during innervation of the vertebrate inner ear is not clearly defined. Here we address the role of fibroblast growth factor 2 (FGF-2 or basic FGF) during development of the chicken inner ear. We found that FGF-2 stimulated survival of isolated cochlear and vestibular neurons during distinct phases of inner ear innervation. The potential neurotrophic role of FGF-2 was confirmed by its expression in the corresponding sensory epithelia and the detection of one of its high-affinity receptors in inner ear neurons. Finally, we have analysed the potential of the amplicon system based on defective herpes simplex virus type 1 (HSV-1) vectors to express FGF-2 in cochlear neurons. Overexpression of FGF-2 in cochlear neurons resulted in neuronal differentiation demonstrating the presence of biologically active growth factor. This study underlines the potential of FGF-2 to control innervation and development of sensory epithelia in the avian inner ear. Furthermore, amplicon vectors may provide a useful tool to analyse gene function in isolated neurons of the vertebrate inner ear.

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Citations

Feb 13, 2003·Journal of Neuroscience Methods·Ignacio Vicario, Thomas Schimmang
Nov 21, 2012·Regenerative Medicine·M Beatriz Durán AlonsoThomas Schimmang
Aug 2, 2007·Expert Opinion on Biological Therapy·Delphine CuchetAlberto L Epstein
Aug 31, 2004·Journal of Neuroscience Research·Estela CarniceroThomas Schimmang
Dec 12, 2012·Developmental Biology·Androulla EconomouMark Maconochie
May 30, 2013·Molecular Medicine Reports·Li Xia, Shankai Yin

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