Roles of gastrointestinal and adipose tissue peptides in childhood obesity and changes after weight loss due to lifestyle intervention

Archives of Pediatrics & Adolescent Medicine
Christian L Roth, Thomas Reinehr

Abstract

Childhood obesity is a global epidemic and associated with an increased risk of hypertension, diabetes mellitus, and coronary heart disease, in addition to psychological disorders. Interventions such as bariatric surgery are highly invasive and lifestyle modifications are often unsuccessful because of disturbed perceptions of satiety. New signaling peptides discovered in recent years that are produced in peripheral tissues such as the gut, adipose tissue, and pancreas communicate with brain centers of energy homeostasis, such as the hypothalamus and hindbrain. This review discusses the major known gut- and adipose tissue-derived hormones involved in the regulation of food intake and energy homeostasis and their serum levels in childhood obesity before and after weight loss as well as their relationship to consequences of obesity. Since most of the changes of gastrointestinal hormones and adipokines normalize in weight loss, pharmacological interventions based on these hormones will likely not solve the obesity epidemic in childhood. However, a better understanding of the pathways of body weight- and food intake-regulating gut- and adipose tissue-derived hormones will help to find new strategies to treat obesity and its conseque...Continue Reading

Citations

Aug 2, 2011·The Proceedings of the Nutrition Society·Thomas Reinehr
May 7, 2011·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·T Reinehr
Apr 2, 2015·International Journal of Food Sciences and Nutrition·Frida Karlsson VidehultChristina E West
Feb 2, 2011·Pediatric Clinics of North America·Donald E GreydanusCynthia Feucht
Apr 18, 2015·Pediatric Diabetes·Thomas ReinehrReinhard W Holl
Oct 11, 2014·Mind, Brain and Education : the Official Journal of the International Mind, Brain, and Education Society·Alison L MillerJulie C Lumeng
Jun 19, 2013·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Anna SijtsmaEva Corpeleijn
Dec 31, 2014·Endocrine·Thomas Reinehr, Christian L Roth
Jan 19, 2012·Journal of Obesity·Christian L RothAndrew N Hoofnagle
Nov 11, 2017·International Journal of Environmental Research and Public Health·Xin GuoYan Yao
Nov 13, 2018·The Journal of Clinical Endocrinology and Metabolism·Christian L RothEllen A Schur
Nov 25, 2017·Nature Reviews. Endocrinology·Thomas Reinehr
Sep 28, 2010·Current Opinion in Lipidology·Thomas Reinehr, Martin Wabitsch
Jun 9, 2018·Current Diabetes Reviews·Badhma ValaiyapathiAmbika P Ashraf
Jul 22, 2016·Journal of Pediatric Endocrinology & Metabolism : JPEM·Cosimo GianniniAngelika Mohn
Oct 20, 2018·Current Diabetes Reports·Thomas Reinehr, Christian Ludwig Roth
Mar 18, 2020·American Journal of Physiology. Endocrinology and Metabolism·Naohiro YanoTing C Zhao
Jul 12, 2018·Hormone Research in Pædiatrics·Christian L RothMartin Wabitsch

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