Roles of heat-shock proteins in innate and adaptive immunity

Nature Reviews. Immunology
Pramod Srivastava

Abstract

Heat-shock proteins (HSPs) are the most abundant and ubiquitous soluble intracellular proteins. In single-cell organisms, invertebrates and vertebrates, they perform a multitude of housekeeping functions that are essential for cellular survival. In higher vertebrates, their ability to interact with a wide range of proteins and peptides--a property that is shared by major histocompatibility complex molecules--has made the HSPs uniquely suited to an important role in organismal survival by their participation in innate and adaptive immune responses. The immunological properties of HSPs enable them to be used in new immunotherapies of cancers and infections.

References

Jan 2, 1992·Nature·M J Gething, J Sambrook
Jan 1, 1986·Annual Review of Biochemistry·S Lindquist
Jan 1, 1988·Annual Review of Genetics·S Lindquist, E A Craig
Mar 1, 1988·Immunology Today·P K Srivastava, L J Old
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·S J UllrichE Appella
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P K SrivastavaL J Old
Mar 15, 1984·International Journal of Cancer. Journal International Du Cancer·P K Srivastava, M R Das
Jan 1, 1994·Immunogenetics·C De SmetT Boon
Nov 1, 1993·Journal of Immunotherapy with Emphasis on Tumor Immunology : Official Journal of the Society for Biological Therapy·N E BlachereP K Srivastava
Oct 1, 1993·The Journal of Experimental Medicine·H Udono, P K Srivastava
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·T J NielandG M van Bleek
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·K SuzueR A Young
Jul 10, 1998·Cell·E C Lai, J W Posakony
Dec 9, 1998·Nature·S L Rutherford, S Lindquist
May 4, 1999·The Journal of Experimental Medicine·R Y ChandawarkarP K Srivastava
May 4, 1999·The Journal of Cell Biology·W C WigleyP J Thomas
Jul 30, 1999·Developmental and Comparative Immunology·P B Armstrong, J P Quigley
Sep 2, 1999·Biochemical and Biophysical Research Communications·A MénoretP K Srivastava
Dec 22, 1999·Immunogenetics·H RammenseeS Stevanović
Dec 28, 1999·Annual Review of Cell and Developmental Biology·A E Johnson, M A van Waes
Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K OhashiH Kolb
Jan 13, 2000·Immunological Reviews·P CresswellG Diedrich
Feb 22, 2000·The Journal of Biological Chemistry·N A LinderothS Sastry

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Citations

May 30, 2009·Archivum Immunologiae Et Therapiae Experimentalis·Shin-ichiro FujiiKanako Shimizu
Mar 21, 2007·Der Urologe. Ausg. A·B A HadaschikM E Gleave
Jul 21, 2005·Cancer Immunology, Immunotherapy : CII·John G FacciponteJohn R Subjeck
Sep 10, 2005·Cancer Immunology, Immunotherapy : CII·Valeria Milani, Elfriede Noessner
May 3, 2005·Cancer Immunology, Immunotherapy : CII·Julie R Ostberg, Elizabeth A Repasky
May 12, 2005·Cancer Immunology, Immunotherapy : CII·Yi ZengEmmanuel Katsanis
Jan 21, 2010·Cancer Immunology, Immunotherapy : CII·Bohan DongLiying Wang
May 4, 2012·Cancer Immunology, Immunotherapy : CII·Andrés TittarelliFlavio Salazar-Onfray
Dec 14, 2004·Springer Seminars in Immunopathology·Pierre Guermonprez, Sebastian Amigorena
Jan 31, 2012·Heart and Vessels·Lyudmila L KapustianLyudmila L Sidorik
Dec 11, 2007·Journal of Cancer Research and Clinical Oncology·Ping ChenYu-Quan Wei
Feb 23, 2011·Clinical Rheumatology·Chih-Te Charles WuJing-Long Huang
Jan 17, 2012·Inflammopharmacology·Nuri KimMidori A Yenari
Jun 19, 2010·Transgenic Research·Giampaolo BurianiSelene Baschieri
Jun 2, 2012·Indian Journal of Microbiology·Gautam Kaul, Hitesh Thippeswamy
Apr 1, 2009·Cell Stress & Chaperones·Daisuke KawashimaKenzo Ohtsuka
Dec 13, 2012·Cell Stress & Chaperones·Sergey V AbkinBoris A Margulis
May 5, 2004·Best Practice & Research. Clinical Gastroenterology·K-G Tranberg
Mar 31, 2004·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Tibor Károly FábiánPál Fejérdy
Mar 20, 2004·Pharmacology & Therapeutics·Amere Subbarao Sreedhar, Peter Csermely
May 8, 2004·Trends in Plant Science·Eric B Holub, Abigail Cooper
Feb 5, 2003·Experimental Cell Research·Sergey Ya ProskuryakovVladimir L Gabai
Nov 6, 2002·Journal of Neuroimmunology·Michael F KollerPhilipp Christen
Nov 5, 2002·Current Opinion in Immunology·Pamela S Ohashi, Anthony L DeFranco
Dec 24, 2002·Current Opinion in Immunology·Julie C Baker-LePainChristopher V Nicchitta
Nov 20, 2003·Methods : a Companion to Methods in Enzymology·Chuanliang LiuMelissa DeFilippo
Apr 13, 2013·Cell Death and Differentiation·C J ChanL Martinet
Jun 30, 2007·Nature Clinical Practice. Rheumatology·Dirk FoellJohannes Roth

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