Roles of hepatocyte growth factor and mast cells in thrombosis and angiogenesis

Cardiovascular Drugs and Therapy
Akira Matsumori

Abstract

Concentrations of the circulating hepatocyte growth factor (HGF) increase in the very early phase of acute myocardial infarction, and are a marker of arterial thrombosis. A recently developed, highly sensitive HGF assay can detect the early stages of arterial thrombosis in patients with unstable angina pectoris, acute aortic dissection and pulmonary thromboembolism. Heparin rapidly induces the release of HGF into the circulation, and HGF is a major factor involved in heparin-induced angiogenesis. Furthermore, the activation of mast cells by thrombus formation releases HGF into the circulation. This new pathway, thrombus formation-mast cell activation- degranulation-heparin-HGF-angiogenesis, may be both diagnostically useful and a therapeutic target.

Citations

Apr 25, 2009·The American Journal of Pathology·Nils BuchsteinSabine A Eming
Mar 8, 2006·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Klas Norrby
Mar 21, 2008·Fundamental & Clinical Pharmacology·Ashish K RehniAmteshwar S Jaggi
Dec 5, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A-R KuehlB Vollmar

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