Apr 24, 2008

Roles of Hes genes in neural development

Development, Growth & Differentiation
Ryoichiro KageyamaTaeko Kobayashi

Abstract

Hes genes are mammalian homologues of Drosophila hairy and Enhancer of split, which encode basic helix-loop-helix (bHLH) transcriptional repressors. In the developing central nervous system, Hes1, Hes3 and Hes5 are highly expressed by neural stem cells. Inactivation of these Hes genes leads to upregulation of proneural genes, acceleration of neurogenesis and premature depletion of neural stem cells. Conversely, overexpression of Hes genes leads to inhibition of neurogenesis and maintenance of neural stem cells. At later stages of development, Hes genes promote gliogenesis. Furthermore, Hes genes regulate maintenance of boundaries, which partition the nervous system into many compartments and endow the neighboring compartments with regional identities by secreting morphogens. Boundary cells usually proliferate slowly and do not give rise to neurons, unlike neural stem cells in compartments. Interestingly, these different characteristics between boundary cells and compartmental neural stem cells are regulated by different modes of Hes1 expression, which is variable in neural stem cells in compartments and persistent and high in boundary cells. Thus, Hes genes play an essential role in neural development by regulating proliferatio...Continue Reading

Mentioned in this Paper

Molecular Helix
HES1 gene
Developmental Biology
Drosophila melanogaster Proteins
Transcription, Genetic
Entire Nervous System
Neurons
Tertiary Protein Structure
Helix (Snails)
Drosophila

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