Roles of HLA-G in the Maternal-Fetal Immune Microenvironment.

Frontiers in Immunology
Xiuxiu XuHaiming Wei

Abstract

During pregnancy, the maternal uterus and fetus form a special microenvironment at the maternal-fetal interface to support fetal development. Extravillous trophoblasts (EVTs), differentiated from the fetus, invade into the decidua and interact with maternal cells. Human leukocyte antigen (HLA)-G is a non-classical MHC-I molecule that is expressed abundantly and specifically on EVTs in physiological conditions. Soluble HLA-G (sHLA-G) is also found in maternal blood, amniotic fluid, and cord blood. The abnormal expression and polymorphisms of HLA-G are related to adverse pregnancy outcomes such as preeclampsia (PE) and recurrent spontaneous abortion (RSA). Here we summarize current findings about three main roles of HLA-G during pregnancy, namely its promotion of spiral artery remodeling, immune tolerance, and fetal growth, all resulting from its interaction with immune cells. These findings are not only of great significance for the treatment of pregnancy-related diseases but also provide clues to tumor immunology research since HLA-G functions as a checkpoint in tumors.

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Citations

Apr 4, 2021·International Journal of Molecular Sciences·Keiichi MatsubaraTakashi Sugiyama
May 8, 2021·Joint, Bone, Spine : Revue Du Rhumatisme·Steve Genebrier, Karin Tarte
Jul 20, 2021·Frontiers in Immunology·Aifen Lin, Wei-Hua Yan
Aug 8, 2021·International Journal of Molecular Sciences·Ricky B van de WaterPeter J K Kuppen
Aug 25, 2021·Cellular & Molecular Immunology·Fuyan WangFrancesco Colucci

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Methods Mentioned

BETA
co-immunoprecipitation assay
RSA

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