Roles of hydrophilicities and hydrophobicities of dye and sacrificial electron donor on the photochemical pathway.

Journal of Photochemistry and Photobiology. A, Chemistry
Pedro Sanchez-CruzAntonio E Alegria

Abstract

Relative rates of the photosensitized production of singlet oxygen ((1)O(2)) and of superoxide (O(2) (•-)) were determined using different couples of dyes and sacrificial electron donors (SEDs) of either high or low hydrophobicities. Such rates were also measured in the absence and presence of single unilamellar vesicles (SUVs) with 9DMPC:1DMPA mol ratio composition. The dyes aluminum phthalocyanine tetrasulfonate (AlPcS(4)) and pheophorbide-a (PHEO) were used as hydrophilic and hydrophobic photosensitizers, respectively. Xanthine (X) and glutathione (GSH) were used as hydrophobic and hydrophilic SEDs, respectively. The presence of SUVs in the aqueous sample produces the physical separation or encounter of SEDs and photosensitizers according to their membrane binding constants. When both the SED and the photosensitizer are localized within the same phase, a strong decrease in the rate of (1)O(2) formation, united to a strong increase in the rate of O(2) (•-) formation, is observed, relative to when both of these species are localized in different phases. The lipid phase is always present in the biological milieu. Thus, the use of a hydrophobic couple of both dye and SED (as in the case of X and PHEO), as well as a hydrophilic c...Continue Reading

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Citations

Sep 2, 2014·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Kamola R KasimovaMichael R Hamblin
Apr 13, 2012·The Annals of Pharmacotherapy·Kristina E E RokasSharon B Weissman

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