PMID: 8002517Aug 1, 1994

Roles of intra- and extracellular carbonic anhydrase in alveolar-capillary CO2 equilibration

Journal of Applied Physiology
T A HemingA Bidani

Abstract

Alveolar-capillary CO2 equilibration involves diffusive equilibration of CO2 across the blood-gas barrier and chemical equilibration of perfusate CO2-HCO-3-H+ reactions. These processes are governed by different, but related, driving forces and conductances. The present study examined the importance of pulmonary carbonic anhydrase (CA) for diffusive and reactive CO2 equilibration in isolated rat lungs. Lungs were perfused with salines containing membrane-impermeant or -permeant inhibitors of CA. Measurements of CO2 excretion rate, equilibrated venous and arterial PCO2 and pH, and postcapillary pH and PCO2 disequilibria were used, together with our previous model of CO2-HCO-3-H+ reactions and transport in saline-perfused capillaries (Bidani et al. J. Appl. Physiol. 55: 75-83, 1983), to compute the relevant driving forces and conductances. Reactive CO2 equilibration was markedly affected by extracellular (vascular) CA activity but not by the activity of intracellular (cytosolic) CA. The driving force for CO2 diffusion was strongly influenced by vascular CA activity. The conductance for CO2 diffusion was independent of CA activity. The minimum conductance for CO2 diffusion was estimated to be 700-800 ml.min-1.Torr-1. The results i...Continue Reading

Citations

Jul 23, 1999·Annals of the New York Academy of Sciences·I NishimoriM A Hollingsworth
May 17, 2008·The Journal of Biological Chemistry·Pawel SwietachRichard D Vaughan-Jones
Mar 25, 2006·The Journal of Physiology·Misa MizumoriYasutada Akiba
Mar 25, 1999·Acta Physiologica Scandinavica·P J WistrandI Mahieu
Apr 7, 2007·Cancer Metastasis Reviews·Pawel SwietachAdrian L Harris

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