PMID: 8977526Dec 1, 1996Paper

Roles of JAK kinases in human GM-CSF receptor signal transduction

The Journal of Allergy and Clinical Immunology
S WatanabeK Arai

Abstract

The receptors for human interleukin-3 (IL-3) and human granulocyte-macrophage colony-stimulating factor (GM-CSF), hIL-3R, hGM-CSFR, respectively, consists of two subunits, alpha and beta, both of which are members of the cytokine receptor superfamily. Phosphorylation of tyrosine residues in the hGMR beta subunit and several cellular proteins is observed after hGM-CSF stimulation. We analyzed the role of tyrosine residues in the hGMR beta subunit and the nature of tyrosine kinase, JAK2, in hGMR signal transduction using several hGMR beta subunit mutants. In addition to the box1 region, a membrane distal region (a.a. 544-589) of the hGMR beta was required for c-fos activation. Only one tyrosine residue (Tyr577) existed within the region 544 to 589, and substitution of Tyr577 to phenylalanine in GMR beta 589 resulted in loss of c-fos activation. In contrast, the same substitution in a wild type receptor did not affect GM-CSF induced activities such as c-fos messenger RNA (mRNA) induction and proliferation, but the substitution abolished Shc phosphorylation. These results suggest that the activation of Shc is not essential for c-fos activation and several tyrosine residues cooperate for c-fos activation. It is well documented that ...Continue Reading

References

Jan 1, 1992·Annual Review of Immunology·A MiyajimaK Arai
Jan 1, 1990·Annual Review of Biochemistry·K I AraiT Yokota
May 1, 1994·Trends in Biochemical Sciences·J N IhleO Silvennoinen
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·O SilvennoinenJ N Ihle

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Citations

May 10, 2001·International Journal of Hematology·C J BagleyA F Lopez
Feb 5, 2002·Annual Review of Physiology·Bruce C Trapnell, Jeffrey A Whitsett
Jan 31, 2009·Journal of Cellular Biochemistry·Wei-Hwa LeeHuei-Mei Huang
Sep 30, 1999·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·G HellgrenB Carlsson
Apr 25, 2000·Blood Cells, Molecules & Diseases·D W WuL M Pelus
Apr 14, 2004·Critical Reviews in Clinical Laboratory Sciences·Chun Kwok WongChristopher Wai Kei Lam
Jun 18, 2002·Immunopharmacology and Immunotoxicology·Chun Kwok WongChristopher Wai Kei Lam
Mar 9, 2019·Nature Reviews. Disease Primers·Bruce C TrapnellCormac McCarthy
Jun 17, 2020·BMC Immunology·Yuya FujitaKiyoshi Migita
Jan 23, 1999·International Reviews of Immunology·M Hibi, T Hirano
Nov 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pratibha C JoshiDavid M Guidot
Mar 7, 2021·Cancers·Juuli RaivolaOlli Silvennoinen
Feb 1, 2000·Biochemical and Biophysical Research Communications·K Ikizawa, Y Yanagihara

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