Roles of mast cells and histamine in mosquito bite-induced allergic itch-associated responses in mice

Japanese Journal of Pharmacology
E OhtsukaYasushi Kuraishi

Abstract

We investigated itch-associated responses (scratching) to mosquito bites and the role of histamine and mast cells in mosquito-induced itching in mice. Although the first bites of mosquito Aedes albopictus did not increase scratching, repeated bites increased scratching. The response was not diminished even after an interval of 2 months. Similarly, repeated intradermal (i.d.) injections of salivary gland extract (SGE) from Aedes albopictus increased scratching after SGE injection itself and mosquito bites. The scratching peaked within 10 min and almost subsided by 60 min. The opioid antagonist naloxone (1 mg/kg, s.c.) inhibited scratching following SGE injection. Although the non-sedative H1-histamine-receptor antagonist terfenadine (30 mg/kg, p.o.) significantly suppressed scratching induced by histamine (100 nmol/site, i.d.) in either naive or mosquito-sensitized mice, it did not affect mosquito-induced scratching in mosquito-sensitized mice. Repeated injections of SGE increased scratching in mast cell-deficient (WBB6F1-W/Wv) mice as well as in normal (WBB6F1-+/+) littermates. Repeated exposure to mosquito bites roughly doubled serum concentrations of total IgE and IgG1, but not IgG2a. Repeated injections of SGE markedly incre...Continue Reading

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Citations

Jan 11, 2003·British Journal of Pharmacology·Tsugunobu Andoh, Yasushi Kuraishi
May 16, 2008·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Tsugunobu Andoh
Apr 2, 2008·Biological & Pharmaceutical Bulletin·Tasuku NakanoYasushi Kuraishi
Nov 5, 2008·Biological & Pharmaceutical Bulletin·Yasushi KuraishiHiroshi Nojima
Jan 26, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ayumi SakamotoYasushi Kuraishi
Apr 17, 2012·Experimental Eye Research·Tsugunobu AndohYasushi Kuraishi
Jun 15, 2011·Neuropharmacology·Yoshikazu GotohYasushi Kuraishi
Oct 19, 2010·European Journal of Pharmacology·Yoshikazu GotohYasushi Kuraishi
Aug 7, 2009·The Journal of Investigative Dermatology·Tsugunobu AndohYasushi Kuraishi
Jun 12, 2004·The Journal of Investigative Dermatology·Tsugunoubu AndohYasushi Kuraishi
Aug 28, 2007·Pharmacology & Therapeutics·Anneke RijnierseAletta D Kraneveld
Aug 23, 2003·The British Journal of Dermatology·Y Ashida, M Denda
Aug 2, 2003·The British Journal of Dermatology·M A HossenC Kamei
May 2, 2012·European Journal of Pharmacology·Tsugunobu AndohYasushi Kuraishi
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Mar 1, 2011·Biochimica Et Biophysica Acta·Salaheddine Mecheri
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